Electrospun tetracycline hydrochloride drug

Kenawy et al. studied the potential of electrospun fiber mats as drug delivery system for the release of tetracycline hydrochloride (Kenawy et al. 2002). Electrospun PEVA + PLA blended fibers were 1—3 pm in diameter while the PLA fibers were around 3-6 pm. Srinivasan and Reneker 1995 examined the crystal structure and morphology of the electrospun Kevlar fibers (Srinivasan and Reneker 1995). Fibers from 40 nm to a few hundreds of nanometers were produced. 

Rather than drag coating onto electrospun surface, Kenawy et al. [51] have examined the behavior of nanofibers composed of PLA and poly (ethylene-acetate co-vinyl) (PEVA) with incorporated drag. The fibers were prepared by dissolving the polymer with tetracycline hydrochloride drag, thereby producing polymeric fibers. This experimentation demonstrates a constant drug release over 5 days from the polymer nanofibers in electrospun PEVA and 50/50 PLA/PEVA mats. 

Electrospun fiber mats explored as drug delivery vehicles using tetracycline hydrochloride as the model drug. 

Numerous other biodegradable polymers that can be electrospun can be applied in wound healing, for example, PLA and block-copolymer derivatives, PCL, chitin, and chitosan. Using tetracycline hydrochloride as a model drug, it was shown that the release kinetics can be adjusted... 

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