P-Mercaptopropionic acid

SYNS l-a-ACETAMIDO-P-MERCAPTOPROPIONIC ACID ACETEIN ACETYLCYSTEINE N-ACETYLCYSTEINE N-ACETYL-N-CYSTEINE N-ACETYL-l-CYSTEINE (9CI) N-ACETYL-3-MERCAPTO-AL.ANINE AIRBRON BRONCHOL-YSIN FLUIMUCETIN FLULMUCIL FLUMICIL INSPIR MERCAPTURIC ACID (R)-MERCAP-TURIC ACID MUCOLYTICUM MUCOLYTICUM LAPPE MUCOMYST MUCOSOLVIN NAC NAC-TB NSC-111180 PARVOLEX RESPAIRE... 

MPA 03-00-00726 (Beilstein Handbook Reference) AI3-26090 BRN 0773807 EINECS 203-537-0 HSDB 5381 Hydracrylic acid, 3-thio- p-Mercaptopropionic acid 2-Mercaptoethanecarboxylic acid ... 

Transfer 14 g chlorobenzaldehyde, 10.6 g P-mercaptopropionic acid and 3.1 g of methyl amine into 100 ml roundbottom flask. The reaction mixture is duly refluxed in benzene for 45-50 minutes and the water (i.e., products of reaction) is suitably removed from an overhead separator. 

CAS 79-42-5 EINECS/ELINCS 201-206-5 UN 2936 (DOT) FEMA 3180 Synonyms 2-Mercaptopropanoic acid a-Mercaptopropanoic acid a-Mercaptopropionic acid P-Mercaptopropionic acid Propanoic acid, 2-mercapto-... 

CAS 107-96-0 EINECS/ELINCS 203-537-0 Synonyms 3-Mercaptopropanoic acid p-Mercaptopropanoic acid Mercaptopropionic acid (INCI) p-Mercaptopropionic acid 3-MPA Propanoic acid, 3-mercapto- 3-Thiopropanoic acid 3-Thiopropionic acid P-Thiopropionic acid... 

In the case of mercaptopropionic acid, biodegradation of 96% was achieved within 28 d ia a closed botde test based oa the consumption of oxygea. The pass level of 60% was reached within 10 d of exceeding the 10% level thus, mercaptopropionic acid can be considered as readily biodegradable. It is not expected to bio accumulate, owing to the low (log P — 0.09) -octanol/water partition coefficient. 

Condensation of p-chlorobenzaldehyde with 3-mercaptopropionic acid in the presence of ammonium carbonate leads to the thiazi-none, 179. The reaction very probably proceeds by the intermediacy of the carbonyl addition product, I7S lactamization completes formation of the observed product. Oxidation of 179 to the sulfone by means of potassium permanganate in acetic acid gives chlormezanone (180), a minor tranquilizer with muscle-relaxant properties. 

Chlormezanone Chlormezanone, 2-(p-chlorophenyl)-tetrahydro-3-methyl-4H-l,3-tiazin-4-on-1,1-dioxide (5.2.8), is synthesized by joint condensation of mercaptopropionic acid, methylamine, and 4-chlorobenzaldehyde, evidently through the intermediate stage of formation of 4-chlorobenzylidenemethylamine, giving the aminothioacetal 2-(p-chlorophenyl)-tetrahydro-3-methyl-4H-l,3-tiazin-4-one (5.2.7). Oxidation of the sulfur atom using potassium permanganate gives chlormezanone (5.2.8) [62,63]. 

Reaction of 4-phenyl-6-chloro-2(lH)-pyridone and 3-aminopropanethiol on heating in ethylene glycol at 190-200°C afforded 8-phenyl 2,3, 4,6-tetrahydropyrido[2,l-6][l,3]thiazin-6-one (79CPB1207). 2,3,4,6,7,116-Hexahydro[l,3]thiazino[2,3-a]isoquinolin-4-ones (204) were obtained in the reactions of 3,4-dihydroisoquinolines and 3-mercaptopropionic acid in the presence of p-toluenesulfonic acid (69FRP155211 87MI1). 

Orange-red diamagnetic complexes of Pd and Pt with mercaptoacetic acid and 3-mercaptopropionic acid have been reported (see p. 390)48 Simple bis-complexes of N-pyrrolidyl monothiocarbamate with Pd and Pt are not formed,50 but i.r. studies indicate that the tetrakis-complexes are bonded through both O and S, although no definite structure has been proposed. Extraction of the metals Pd, Pt, Ag, and Au from aqueous solution by a large number of alkyl and alkene disulphides and sulphides has been reported (see p. 390).51,52... 

The second method consists in the reaction of 3-mercaptopropionic acid amides with various aldehydes and ketones (method B) this reaction proceeds via the formation of thiohemiacetal 143. Method B was modifed (in the case of p-chlorobenzaldehyde) by means of dithioacetal 144, which was isolated and then introduced into the reaction with the second mole of aldehyde (Scheme 49). 

SYNS 2,2-DIBUTYLDIHYDRO-6H-l,3,2-OXATHIASTANNIN-6-ONE 2,2-DIBUTYL-l-OXA-2-STANNA-3-THIACYCLOHEXAN-6-ONE DIBUTYLTIN-0,S-MERCAPTOPROPIONATE DIBUTYLTIN-S,0-3-MERCAPTOPROPIONATE DIBUTYLTIN-S,0-p-MERCAPTOPROPIONATE DIBUTYL(3-MERCAPTO-PROPIONATO(2-))TIN MERCAPTO-PROPIONIC ACID, DIBUTYLTIN SALT... 

The data for this solvent were not used to calculate the parameters in Table 54. Similarly the data for decarboxylation of oxanilic acid in anisole were not used for the AH -AS correlation. With the reported AH value of 32.6 kcal.mole , the entropy of activation is calculated to be 3.59 0.03 eu compared to the reported value of 11.1 eu. In the decarboxylation of malonic acid, the data obtained with pyridine and ) -mercaptopropionic acid solvents deviated considerably from the plots and were not included in the correlation. The data for malonic acid decarboxylation appeared to be best correlated by two lines. One line was described by the following solvents acids, phenols, nitro-aromatics, benzaldehyde, and the melt the other line involved amines, alcohols, dimethylsulfoxide and triethyl phosphate. The latter line was not as well defined as the former. However, it was our intention to correlate as many solvents as possible with a minimum number of lines. The data for decarboxylation of malonic acid in water and in benzyl alcohol fell between these two lines and were not included in either correlation. The data for decarboxylation of benzylmalonic acid also appeared to be best correlated with two lines. One line was defined by the cresols, acids and the melt, while the other line was defined by the amines. Decarboxylation of cinnamalmalonic acid was correlated by two lines as indicated in Table 54. Similarly j8-resorcylic acid was correlated by two lines. The separation of data into parallel lines is presumably due to multiple solvation mechanisms . In support of this interpretation it is seen that when two lines are observed, acids fall into one line and amines into the other. It is not unexpected that the solvation mechanisms for these two classes of solvents would differ. It is interesting to note that all of the nitrogen containing acids are correlated reasonably well with one line for both basic and acidic solvents. Also the AHq values fall in a rather narrow range for all of the acids. From the values of p in Table 54, there appears to be little correlation between this parameter and the melting point of the acids, contrary to prior reports " ... 

Figure 8-12. Left Monolayer protein voltammetry of P. furiosus ferredoxin on an Au(lll)-electrode modified by a mercaptopropionic acid (MPA) SAM, cf, Fig. 8-lOC 5 mM phosphate buffer, pH 7.9. Scan rate 5 mV s . Middle In situ STM image of P. furiosus ferredoxin molecules in electron transport action on the same MPA-modified Au(lll)-electrode surface Ar-atmosphere. Working electrode potential -0.35 V (SCE), bias voltage -0.35 V. Tunneling current 0.10 nA. Right Schematic view of the P. furiosus ferredoxin molecule on the MPA-modified Au( 111 )-surface. From ref. 137 with permission.

L-Alanine, 3-mercapto- 2-Amino-3-mercaptopropanoic acid, (R)- 2-Amino-3-mercaptopropionic acid L-2-Amino-3-mercaptopropanoio acid R)-2-Amino-3-mercaptopropanoic acid a-Amino-P-thiolpropionic acid a-Amino-p-thiolpropionio acid, L- a-Amino-p-mercaptopropanoic acid, L- AI3-26559 CCRIS 912 Cisteina Cisteinum Cystein Cysteine L-Cysteine L-(+)-Cysteine Cysteine, L- (R)-Cysteine Cysteinum EINECS 200-158-2 FEMA No. 3263 Half cystine HSDB 2109 NSC-8746 Thioserine. A nonessentiai amino acid biochemical and nutrition research, reducing agent in... 

Kutlan, D., Presits, P., and Molnar-Perl, I. Behavior and characteristics of amine derivatives obtained with o-phthaldialdehyde/3-mercaptopropionic acid and with o-phthaldialdehyde/Al-acetyl-L-cysteine reagents. J. Chromatogr. A 949, 235, 2002. 

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