Mercaptoacetic acids

Elemental and inorganic compounds Manganese cyclopenta-dienyl tricarbonyl as Mn Manganese methyl-pentadienyl tricarbonyl Manganese tetroxide Man-made mineral fibre Marble, see Calcium carbonate Mercaptoacetic acid, see Thioglycolic acid Mequinol (INN)... 

In another series of experiments, a novel approach to the determination of nucleotide sequence was adopted by A. S. Jones, Stacey, and their co-workers. For example, when calf thymus DNA was treated with mercaptoacetic acid in the presence of zinc chloride and anhydrous sodium sulfate, it yielded aldehydo-apurinic acid bis(carboxymethyl) dithioacetal. When degraded with dilute alkali, this afforded dialyzable fragments, which were separated into at least 20 components. Some were identified, including mono-, di-, and tri-nucleotides, thereby revealing that DNA contain regions of at least three linked pyrimidine nucleotides. The same procedure was applied to the DNA isolated from M. phlei ... 

The rapid synthesis of 4-thiazolidinones by the MCR of an amine, aldehyde and mercaptoacetic acid has been developed under microwave-assisted conditions [73-75]. Irradiation of the three components in ethanol at 120 °C in the presence of molecular sieves [73] or in toluene at reflux under atmospheric conditions [74] in a single-mode microwave synthesizer gave the... 

The one-pot synthesis of thiazolo[3,4-a]benzimidazoles has been reported using a microwave-assisted condensation-cyclization (see Scheme 17) of a substituted 1,2-diamine, substituted benzaldehyde and mercaptoacetic acid [74]. Heating the mixture at reflux for 12 min using a single-mode microwave reactor for the most part gave the fused benzimidazoles in improved yield and dramatically shorter times, when compared to classical conditions of heating at reflux in benzene for 24-48 h (Scheme 29). 

A small library of thiazolidinones 138 has been prepared mixing directly a primary amine (as the HCl salt), an aldehyde and mercaptoacetic acid in EtOH in the presence of Hiinig s base and molecular sieves (120 °C for 30 min) [88]. Working with a chiral amine, a 1 2 mixture of diastereoisomers was obtained (Scheme 49). 

High density brine completion fluids also often require the use of corrosion inhibitors (8,9). Blends of thioglycolates and thiourea alkyl, alkenyl, or alkynyl phosphonium salts thiocyanate salts mercaptoacetic acid and its salts and the reaction products of pyridine or pyrazine derivatives with dicarboxylic acid monoanhydrides have been used as high density brine corrosion inhibitors. 

The group of Bolognese has disclosed a synthesis of thiazolidin-4-ones by condensation of benzylidene-anilines and mercaptoacetic acid (Scheme 6.215 a) [386]. The authors found that microwave heating of an equimolar mixture of the two components in benzene at 30 °C for just 10 min provides excellent yields of the thiazol-idin-4-one heterocycles. Surprisingly, when the same transformation was carried out at reflux temperature (80 °C), much longer reaction times (2 h) were required and the products were obtained in significantly lower yields (25-69%). 

More recently, Miller and coworkers have reported a one-pot protocol for the preparation of thiazolidin-4-ones by condensation of aromatic aldehydes, amines, and mercaptoacetic acid in ethanol (Scheme 6.215 b) [387]. The optimized procedure involved microwave irradiation of a mixture of the amine hydrochloride, aldehyde,... 

Mixture of 62.82% dipropylene glycol, 21.18% mercaptoacetic acid, 6% n-hexanoic acid, 6% N-methyl morpholine, 2.18% p-cresyl isovalerate, 0.91% 2-naphthalenethiol, and 0.91% skatole. 

This gap in our knowledge is now closed, as the first paper on the uncatalyzed outer-sphere oxidation of an aliphatic thiol was recently published (12).This work selected thioglycolic acid (TGA, mercaptoacetic acid, HSCH2CO2H) as a representative thiol because of its high water solubility, low vapor pressure, and simple structure. The oxidant was [IrCle]2-, a well-characterized one-electron oxidant that frequently reacts through an outer-sphere mechanism. As is typical of such... 

Mercaptoacetic acid could be used as a versatile synthon for the synthesis of 17/,3//-thiazolo[3,4-tf]benzimidazole-type compounds <1996FA279, 1997FA673>. For instance, 2,3-diaminopyridine and 2-mercaptoacetic acid were reacted in a three-component reaction with a suitable carbonyl compound and provided the 17/,3//-thiazolo[3,4- ]-imidazo[4,5- ]pyridines 451 (Equation 212) <1994FA345>. 

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