P-Resorcylic acid

The reaction is particularly facile with di- and tri-hydric phenols. Thus p-resorcylic acid is readily obtained by passing carbon dioxide through a boiling aqueous solution of the potassium or sodium salt of resorcinol ... 

DIHYDROXYL NDECYL)-P-RESORCYLIC ACID-n-LACTONE see RBFIOO l-a,24(R)-DIHYDROXYVlTAMIN D3 see SBL600... 

P-resorcylic acid. (BRA 2,4-dihydroxyben-zene carboxylic acid 2,4-dihydroxybenzoic acid 4-hydroxysalicylic acid 4-carboxyresorci-nol). 

D. (P-resorcylic acid, mp. 216-221 °C, pK 3.22) is used in the production of dyes, drugs, and cosmetics. The methyl ester of 2-hydroxy-4-methoxybenzoic acid (primrose camphor, C9H10O4, Mr 182.18, mp. 49 °C) as well as its 2-O-glycoside primeverin occur in primrose species. 

Bromo-2 4>dihydroxybenzoic Acid. See 3-Bromo-p-resorcylic Acid. 8>Bromo>2 4-dihydroxybenzolc Acid. See 5-Bromo- -resorcylic Acid. 

The resorcylic acid lactones (RALs) are a family of benzannulated macrolides, which are produced by a variety of fungi and show versatile biological activities (6). According to their name, they consist structurally of a partially substituted p-resorcylic acid scaffold, which is linked to a 12- or 14-membered macrolactone moiety. Selected members of this group are shown in Fig. 9.1. 

Mulberrofuran M (142) 120), an amorphous powder, [a]o -1-15°, had molecular formula C34H22O10, and gave a tetraacetate (142a). The UV spectrum had maxima at 208 (51000), 225 (inflection, 26000), 261 (20000), 299 (inflection, 18000), 323 (shoulder, 28000), 335 (34000) and 350 nm (shoulder, 28000), and was similar to those of other 4 -sub-stituted 6,3, 5 -trioxygenated 2-arylbenzofuran derivatives. The C-NMR spectrum of 142 is listed in Table 5. Hydrolysis of mulberrofuran M with 10% H2SO4 in methanol gave P-resorcylic acid methyl ester and a compound (142 ) were obtained. Considering the spectral data of 142,142 a, and 142, formula 142 was proposed for mulberrofuran M. 

Also obtained by photo-Fries rearrangement of resorcinol monobenzoate [219], Preparation by reaction of di(carbomethoxy)-P-resorcylic acid chloride with benzene in the presence of aluminium chloride at 60-70° for 1 h, then at 80° for 1 h (70%) [220],... 

Preparation by reaction of P-resorcylic acid with phenol in the presence of zinc chloride and a mixture of polyphosphoric acid/85% phosphoric acid (60 40) at 27° [194], (40%) [380]. Then, during 2 h, phosphorous trichloride was added between 27° and 37° and the nuxture heated at 60° for 16 h [194],... 

Preparation by reaction of p-resorcylic acid with resorcinol,... 

Preparation by reaction of P-resorcylic acid with pyrogaUol,... 

Also obtained by action of P-resorcylic acid with resorcinol in the presence of zinc chloride for 45 min at 125-140° [1505]. 

Also obtained by Friedel-Crafts propionylation of 5-bromo-P-resorcylic acid [6450]. 

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