Minor tranquilizers

CifiHijClNj. White plates m.p. 125 C. Diazepam is one of several benzodiazepines which are very widely used as minor tranquillizers for allaying anxiety, as hypnotics or, in sufficiently high dosage given intravenously, as pre-anaesthetic sedatives. 

Fused isoxazoles (631) were prepared as GABA analogs (75MI41604) and some exhibited CNS depression effects (74JAP(K)7480062) or were effective as minor tranquilizers, muscle relaxants and/or sleep inducers (76USP3966748, 79USP4163057). 

Condensation of p-chlorobenzaldehyde with 3-mercaptopropionic acid in the presence of ammonium carbonate leads to the thiazi-none, 179. The reaction very probably proceeds by the intermediacy of the carbonyl addition product, I7S lactamization completes formation of the observed product. Oxidation of 179 to the sulfone by means of potassium permanganate in acetic acid gives chlormezanone (180), a minor tranquilizer with muscle-relaxant properties. 

Minor tranquilizer. A drug useful in the control of anxiety. Also referred to as anxiolytic. 

Therapeutic Function Minor tranquilizer Chemical Name 2-Phenyl-1,2-butanedioM-carbamate Common Name Oxyfenamate Structural Formula ... 

The lactam moiety in benzodiazepines is active toward nucleophiles and numerous analogues have been made by exploiting this fact. For example, heating demoxepam (3) with N-cyclopropylmethylamine leads to amidine formation, the minor tranquilizer cyprazepam... 

Benzodiazepines. These medications are also known as minor tranquilizers. In general, they have been found less effective than antipsychotics in treating agitation over the long term. However, their relatively quick onset of action makes them effective for acute episodic agitation. 

Antipsychotics are drugs that have a specific sedative effect, and which improve the attitude and calm the behavior of psychotic patients. They do not cause dependence, and have been proposed for treating psychotic disorders (elimination of psychotic symptomatology— delirium, hallucinations) and schizophrenic patients. Drugs of this group are also frequently referred to as neuroleptics. The term major tranquilizer was used previously to distinguish them from minor tranquilizers/anxiolytics. 

Sedatives (also called hypnotics, sedative-hypnotics, minor tranquilizers, antianxiety agents) Secobarbital (barbiturate) Glutethimide (nonbarbiturate hypnotic) Diazepam (benzodiazepine antianxiety agent) Chloral hydrate (miscellaneous hypnotic) alcohol ( substance )... 

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