Leukemia P388 cells, cytotoxic effect

Trimethylgermyl derivatives of 2,-deoxyuridine131 exhibit antimetabolic properties the ft-anomer possesses weak biological action, the a-anomers inhibits the replication of herpes simplex virus HSV-1131 132, reveal cytotoxic properties in vitro experiments on cell culture of human ovary carcinoma CaOv and fail to display antitumor action in vivo to leukemia P388 in mice. The a-anomer of 5-trimethylgermyl-2,-deoxyuridine suppresses the incorporation of 2,-deoxyuridine and thymidine into the DNA of hepatoma 22A cells in vitro more effectively (by 88 and 27%) than the ft-anomer (50 and 0%, respectively). 

Murraya koenigii (L.) Spreng (Rutaceae) was evaluated for its in vitro cytotoxic effects against MCF 7, P388 (murine leukemia) and Hela cells. The results showed that both, the EO and its main compound carbazole alkaloids have signi cant antiproliferative effects on all three tested cell lines in a dose- and time-dependent manner (Nagappan et al., 2011). 

Not only [jj]-annelated fluoroquinolones, but also polycyclic fluoroquinolones, in which an additional ring is annelated to [c]- or [/ ]-sides proved to possess antineoplastic action. Research studies on antineoplastic activity of 5-cyclopropyl-6,8-difluoro-7-(2,6-dimethyl-4-pyridinyl)-5H-pyrazolo[4,3-c] quinolin-3(2H)-ones 106 have shown that derivatives containing the cyclohexyl group in position 2 are the most effective inhibitors of topoisomerase II of HeLa cells (mammalian cancer), while the dimethylaminocyclohexyl compound has shown the best data on cytotoxicity towards P388 (leukemia) cells (Table 9) [312]. 

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