Overall Architecture

Figure 15.6 Overall architecture of approach used for multiobjective compound selection [101].

There are a variety of factors concerning siderophore architecture that can contribute to the stability of iron-siderophore complexes. The overall architecture for natural multidentate siderophores can be any one of a number of different types linear,... 

Cyclic nucleotide-modulated ion channels (Table 6-2) are not K+-selective. Nevertheless, their inward current of Na+ and Ca2+ ions is conducted through a channel that is similar in overall architecture to Shaker K+ channels. This protein family includes the CNG channels, which respond only to cyclic nucleotides, and the HCN channels, which are activated synergistically by hyperpolarization and cyclic nucleotide binding [38,40]. The CNG channels are involved in signaling of visual and olfactory information and serve as cyclic nucleotide-gated Ca2+ channels. In contrast, the HCN channels are required for normal rhythmic electrical discharges by the sinoatrial node in the heart and the pacemaker cells of the thalamus. 

Another possible explanation for the limitations of catalytic antibodies raised against TSA can be found in the different accessibility of the active site. In the case of natural enzymes, it is that their catalytic machinery and bound substrates are often buried. This feature isolates from the solvent the reactive functionalities that mediate chemical transformations. On the contrary, in antibody catalysis, the moieties of the bound haptens that mimic the TS are often positioned near the entrance of the antibody-combining site. This disparity in the overall architecture of natural enzymes and catalytic antibodies is undoubtedly a factor in the lower catalytic... 

The LEDs of the ERa and the ER/1 share a similar overall architecture. Two separate transactivation domains (AF) mediate the transactivation of the ER an N-terminal hgand-independent activation fimction (AF-1) and a C-terminal ligand-dependent activation function (AF-2), which is located within the LED (Fig. 3). The surface of the AF-1 is composed of amino acids in helices 3,4, 5 and 12, and the binding of ligands alters the position of heHx... 

The thermochemistry parameters are some of the most useful results of quantum computation. The important features of the overall architecture of a molecule include the connectivity or topology, flexibility, vibration modes and frequencies, shape, moments of inertia, rotational energies and frequencies, and the overall symmetry. The shape of a molecule plays an important part in many of its properties. Some of the most interesting and easy to describe are the long and narrow rod-like eicosane, C20H44, the disk-shaped coronene, C24H12, and the sphere-shaped methane, CH4, adamantine, C10H16, and buckminsterfullerene, C6o-... 

The salient features of A. faecalis pseudoazurin are that (1) it has a Cu-Met bond length shorter than that of either plastocyanin or azurin (see Table III) (2) it has only one NH - S bond, as does plastocyanin and (3) its overall architecture resembles plastocyanin (see Fig. 4), with an extended carboxy terminus folded into two a helices [a preliminary sequence comparison suggested that the folding would resemble plastocyanin (Adman, 1985)]. It retains the exposed hydrophobic face found in azurin and plastocyanin. Just how it interacts with nitrite reductase is still a subject of investigation. It is intriguing that the carboxy-terminal portion folds up onto the face of the molecule where the unique portions of other blue proteins are the flap in azurin, and, as we see below in the multi-copper oxidase, entire domains. 

Then, the healthy signal is used to feed a bank of /Vp + 1 nonlinear adaptive observers (where /Vp is the number of the possible process/actuator faults). The first observer is in charge of detecting the occurrence of process/actuator faults. The other /Vp observers, each corresponding to a particular type of process/actuator fault, achieve fault isolation and identification by adopting a suitable adaption mechanism. Figure 6.3 shows a block diagram representation of the overall architecture. 

Since the term cryptand only refers to crown ether derived polycyclic receptors, polycyclic systems deriving from other structural motifs are commonly termed molecular cages or molecular capsules, although other names such as nanospheres, nanoflasks, temple-type receptors, etc., can also be found. The word cage well illustrates the overall architecture of many of these receptors, consisting of a floor and a roof connected by at least three bars.1 For self-assembled receptors, on the other hand, the term molecular capsule is often more appropriate. 

Figure 2.2 Overall architectural comparisons of type 1, 2, and 3 (SABATH) plant MTs discussed in this chapter and rendered as backbone ribbon diagrams.

The copper coordination geometry is also variable in this structural set. While mononuclear square-pyramidal sites are most common, mononuclear six-coordinate and even binuclear sites are also incorporated into the overall architectures. Water coordination is also evident, often giving rise to more than one coordination geometry in a material, as illustrated by 1, 4, 5 and 8. 

El Kabbani, O., Chang, C. H., Tiede, D., Norris, J., and Schiffer, M., 1991, Comparison of reaction centers from Rhodobacter sphaeroides and Rhodopseudomonas viridis Overall architecture and protein-pigment interactions. Biochemistry, 30 5361-5369. 

Although the alphaviruses and flaviviruses share similarities in overall architecture as icosahedral enveloped viruses and exhibit striking structural similarities in their fusion proteins, several aspects of their... 

Figure 23.7. Proteasome Evolution. The archaeal proteasome consists of 14 identical a subunits and 14 identical P subunits. In the eukaryotic proteasome, gene duplication and specialization has led to 7 distinct subunits of each type. The overall architecture of the proteasome is conserved.

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