Antibody catalytic

There is another approach that is increasingly part of synthesis the use of enzymes as catalysts. This approach is strengthened by the new ability of chemists and molecular biologists to modify enzymes and change their properties. There is also interest in the use of artificial enzymes for this purpose, either those that are enzyme-like but are not proteins, or those that are proteins but based on antibodies. Catalytic antibodies and nonprotein enzyme mimics have shown some of the attractive features of enzymes in processes for which natural enzymes are not suitable. 

While the presentation thus far has emphasized the programmed relationship of hapten design and consequent antibody catalytic activity, there is a growing number of examples where the detailed examination of catalysis reveals mechanistic features that were not evidently design features of the system at the outset. Such discoveries are clearly a strength rather than a weakness of... 

Antibodies, Catalytic, Stereoselective Reactions with (Hilvert) 22 83... 

Sonkaria S, Boucher G, Horez-Alvarez J et al. (2004) Evidence for lock and key character in an anti-phosphonate hydrolytic antibody catalytic site augmented by non-reaction centre recognition variation in substrate selectivity between an anti-phosphonate antibody, an anti-phosphate antibody and two hydrolytic enzymes. Biochem J 381 125—130 Sprossler B, Plainer H (1983) Immobilized lactase for processing whey. Food Technol 37 93-96 Stemmer WP (1994) Rapid evolution of a protein in vitro by DNA shuffling. Nature 370 389-391 Sticklen M (2006) Plant genetic engineering to improve biomass characteristics for biofuels. Curr Opin Biotechnol 17(3) 315-319... 

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