Overactive bladder drug

Hashim H, Abrams P. Treatment of overactive bladder. Drugs 2004,64 1644-1654. 

Anonymous. Tolterodine offers new hope for those with overactive bladder. Drugs Ther Perspect 1999 13 1-4. 

Clemett D, Jarvis B. Tolterodine a review of its use in the treatment of overactive bladder. Drugs Aging 2001 18(4) 277-304. 

Discuss the uses, general drug actions, adverse reactions, contraindications, precautions, and interactions of the drugs used to treat infections and symptoms associated with urinary tract infections or an overactive bladder. 

Discuss important preadministration and ongoing assessment activities the nurse should perform on the patient taking a drug for a urinary tract infection or an overactive bladder. 

Discuss ways to promote an optimal response to therapy, how to manage adverse reactions, and important points to keep in mind when educating patients about the use of drugs used to treat a urinary tract infection or symptoms associated with an overactive bladder. 

This chapter discusses drug s used to treat urinary tract infections (UTIs) and certain miscellaneous drag > used to relieve the symptoms associated with an overactive bladder (involuntary contractions of the detrusor or bladder muscle). Structures of the urinary system that may be affected include the bladder (cystitis), prostate gland (prostatitis), the kidney, or the urethra (see Pig. 47-1). These drug s also help control the discomfort associated with irritation of the lower urinary tract mucosa caused by infection, trauma, surgery, and endoscopic procedures. 

Guay DRP. Drug forecast Darifenacin another investigational anticholinergic for overactive bladder. Consult Pharm 2005 20 424-431. 

Overactive bladder Anticholinergic agentyantispas-modics Oxybulynin TDS (5.9 mg/day apply one patch twice weekly), tolterodine IR (1-2 mg twice daily), tolterodine LA (2-4 mg daily), trospium chloride (20 mg once or twice daily), solifenacin (5-10 mg daily), darifenacin (7.5-15 mg daily) Anticholinergics are first-line drug therapy (oxybulynin or tolterodine is preferred). 

Ades PA, Bailor DL, Ashikaga T et al. (1996) Weight training improves walking endurance in healthy elderly persons. Ann Intern Med 124(6) 568-572 Andersson KE (1997) The overactive bladder pharmacologic basis of drug treatment. Urology 50(6A Suppl) 74-84... 

NS normal saline NSAID nonsteroidal antiinflammatory drug NSCLC non small cell lung cancer NSS normal saline solution NYHA New York Heart Association OAB overactive bladder OCD obsessive-compulsive disorder OCP oral contraceptive pill (birth control pills)... 

Coin E, Digesu GA, Olivieri L. Overactive bladder treatments in early phase clinical trials. Expert Opin Inves-tig Drugs 2007 16 999-1007. 

Hay-Smith J, Herbison P, Ellis G, Moore K. Anticholinergic drugs versus placebo for overactive bladder syndrome in adults. Cochrane Database of Systematic Reviews 2003 3. 

Geriatric Considerations - Summary Flavoxate has anticholinergic activity and has the potential to cause adverse effects in the older adult, including urinary retention, hypotension, and confusion. There are no well controlled studies that show efficacy over placebo in the treatment of the overactive bladder. The potential for adverse effects limits the usefulness of this drug for older adults. 

Staskin DR Overactive bladder in the elderly A guide to pharmacological management. Drugs Aging 2005 22 1013. [PMID 16363885]... 

Consumer Reports, Overactive Bladder Summary of Recommendations, Consumer Reports Health.org. Available online. URL http //www.consumerreports. org/health/best-buy-drugs/bladder.htm. Downloaded April 12, 2009. 

Trospium is a QTA in which the tropine N-atom is part of two alkyl ring structures (Fig. 1). This drug acts as an antimuscarinic agent that is clinically used as orally administered first-line urinary antispasmodic to treat overactive bladder (OAB) [34], Due to the absence of significant biotransformation, trospium is excreted mainly unchanged into urine allowing to exhibit primarily local activity [84],... 

Propiverine is an anticholinergic drug, used mainly for its effects on the bladder. It is effective in detrusor hyper-reflexia and in patients with symptoms of an overactive bladder. Adverse effects occur in about 13% of patients (1). 

Abrams P, Malone-Lee J, Jacquetin B, Wyndaele JJ, Tammela T, Jonas U, Wein A. Twelve-month treatment of overactive bladder efficacy and tolerabihty of tolterodine. Drugs Aging 2001 18(7) 551-60. 

Hegde SS, Mammen M, and Jasper JR (2004) Antimuscarinics for the treatment of overactive bladder Current options and emerging therapies. Current Opinion in Investigational Drugs 5 40-49. 

Andersson K-E. Treatment of overactive bladder other drug mechanisms. Urology 2000 55 Suppl 5A 51-57. 

Andersson K-E. The overactive bladder Pharmacologic basis of drug treatment. Urology 1997 50(6A Suppl) 74—84. 

Chancellor M, Freedman S, Mitcheson HD, et al. Tolterodine, an effective and well tolerated treatment for urge incontinence and other overactive bladder symptoms. Clin Drug Invest 2000 19 83-91. 

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