Trospium chloride

Details regarding the pharmacokinetics, contraindica-tions/precautions, and dosing of the five recommended agents (oxybutynin, tolterodine, trospium chloride, solifenacin, and darifenacin) are illustrated in Table 50-3.7 12,14 16 A current clinical controversy is which of these agents should be considered first-line in UUI, and in the case of oxybutynin and... 

Parameter Oxybutynin Tolterodine Trospium chloride Solifenacin Darifenacin... 

Guay DRP. Trospium chloride an update on a quaternary anticholinergic for the treatment of urge urinary incontinence. Ther Clin Risk Manag 2005 1 157-166. 

Trospium chloride, a quaternary ammonium drug (Fig. 7.45), appears to be a substrate of P-gp, and it can be taken up by cells quicky [597]. The evidence for transmembrane diffusion appears substantial. The molecule is very soluble in water (>50 mg/mL), but not in lipids (9.2 pg/mL in mineral oil) the octanol-water log Kp is —1.22 [598]. The human intestinal absorption (HIA) is 11% the molecule is not metabolized. In cell intestinal patch uptake studies, trospium is absorbed from a... 

Overactive bladder Anticholinergic agentyantispas-modics Oxybulynin TDS (5.9 mg/day apply one patch twice weekly), tolterodine IR (1-2 mg twice daily), tolterodine LA (2-4 mg daily), trospium chloride (20 mg once or twice daily), solifenacin (5-10 mg daily), darifenacin (7.5-15 mg daily) Anticholinergics are first-line drug therapy (oxybulynin or tolterodine is preferred). 

Trospium chloride, a quaternary ammonium anticholinergic, is superior to placebo and is equivalent to oxybutynin IR and tolterodine IR. However, clinical studies are limited by their focus on cystometric rather than clinical endpoints, small absolute benefits compared with placebo, and lack of comparisons with LR formulations. 

Trospium chloride causes the expected anticholinergic adverse effects with increased frequency in patients >75 years old. 

TROSPIUM CHLORIDE The recommended dose is 20 mg twice daily. Dose at least 1 hour before meals or give on an empty stomach. 

Trospium chloride another anticholinergic for overactive bladder. Med Let 2004 46 63-64. 

Pietzko, A., et al. 1994. Influences of trospium chloride and oxybutynin on quantitative EEG in healthy-volunteers. Eur J Clin Pharmacol 47 337. 

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