Over-aging

A batch of 7000 series aluminium alloy rivets for an aircraft wing was inadvertently over-aged. What steps can be taken to reclaim this batch of rivets ... 

The rate at which ageing occurs depends on the ageing temperature. At very low ageing temperatures, over-ageing is not observed in a realistic time... 

Turbuhaler management of chronic asthma in adults and children over age 6 ... 

The National Survey on Drug Use and Health found that 1.6% of persons over age 12 years reported using heroin at some time in their lives (Substance... 

In patients younger than age 65 with overt hypothyroidism, the average LT4 replacement dose is 1.6 mcg/kg per day (use ideal body weight in obese patients25). If there is no history of cardiac disease, these patients may be started on the full replacement dose. The full replacement dose in patients over age 75 is lower, about 1 mcg/kg per day.26 In the elderly, the starting dose is 25 to 50 meg/day, and the dose is titrated to the... 

Subclinical or mild thyrotoxicosis is defined as a low TSH with a normal FT4 level. While there may be few or no symptoms in these patients, there are several areas of concern.31,32 Many patients will progress to overt thyrotoxicosis. Patients with subclinical hyperthyroidism have been shown to suffer long-term cardiovascular and bone sequelae. In a 10-year follow-up of 2007 patients over age 60,33 patients with an undetectable TSH level had a 3.1-fold increased risk of atrial fibrillation versus those with a normal TSH. In a different 10-year follow-up study34 of... 

Specifically, for women with PCOS, the use of depot and intermittent oral medroxyprogesterone acetate suppresses pituitary gonadotropins and circulating androgens.15 Further, the use of cyclic progesterone may benefit women over age 40 and in whom anovulatory bleeding occurs.11... 

Anemia is a common condition, and the prevalence of anemia varies widely based on age, gender, race/ethnicity, and comorbid conditions. A study of anemia prevalence in a nationally representative sample of community-dwelling individuals describes how anemia differs across different populations.1 The prevalence of anemia in children (ages 1-16 years) was 6% to 9%, but the prevalence of anemia increases to approximately 11% in adults over age 65 years and to at least 20% in adults 85 years of age and older. Anemia is generally more common in women, particularly during their reproductive years (ages 17-49 years), when anemia occurs in over 12%, but in less than 2% of men. The same study showed that in the population over age 65, non-Hispanic whites and Mexican Americans had similar prevalence of anemia (9.0% and 10.4%, respectively), but with a prevalence of 27.8%, anemia was significantly more common in non-Hispanic blacks. 

Benign prostatic hyperplasia (BPH) is one of the most common problems of elderly men, affecting more than 40% of men over age 70. BPH results in the urinary symptoms of hesitancy and frequency. Since prostate cancer affects a similar age group and often has similar presenting symptoms, the presence of BPH often complicates the diagnosis of prostate cancer, although it does not appear to increase the risk of developing prostate cancer.2,5... 

Therefore, the use of finasteride to prevent prostate cancer is currently under debate.7 Because of its established benefit in treating BPH, the 20% to 30% of men over age 50 with BPH may derive the additional benefit of prostate cancer prevention and should be offered treatment with finasteride. In the 70% to 80% of men without BPH, the benefits, side effects (primarily impotence), and risks of finasteride should be discussed prior to initiating therapy. 

Precipitates, over-aged, 13 502 Precipitating (cathodic) corrosion inhibitors, 26 144, 145 Precipitation... 

The answer is B. LHON often has an onset in early adulthood. It is a mitochondrial disorder usually resulting from a mutation in one of the proteins of the electron transport chain, particularly complex I, encoded by the mitochondrial genome so there is no chance that the patient can pass the disorder to his children (see Chapter 13). Cataracts would have been detected as opacity in the lenses, and glaucoma would have been identified by an elevated intraocular pressure. Macular degeneration is also associated with central vision loss but is found mainly in patients over age 65. 

Alzheimer s disease, the most prevalent form of dementia, afflicts approximately 10% of the population over age 65. The cardinal features of Alzheimer s disease are progressive loss of memory and disordered cognitive function. Alterations in behavior and a decline in Ian-... 

Two recently introduced biological therapies were designed to interfere with the inflammatory cascade initiate by TNF-a. Etanercept (Enbrel) is indicated for the treatment of moderate to severe rheumatoid arthritis in individuals over age 4. Infliximab in conjunction with methotrexate (Remicade) is approved for use by adults in the treatment of rheumatoid arthritis. It is also indicated for therapy of Crohn s disease. Over the short term, the efficacy of these drugs in the treatment of rheumatoid arthritis appears to be superior to that of methotrexate alone however, their ability to prevent bone erosion for longer than 24 months must be further studied. The cost of both drugs is significantly higher than that of the other DMARDs. 

An aberrant immune response associated with allergy appears to underlie asthma in most children over age 3 years and in most young adults allergy-induced asthma is also known as extrinsic asthma. In contrast, a large number of patients, especially those who acquire asthma as older adults, have no discernible immunological basis for their condition, although airway inflammation remains a characteristic of the disease this type of... 

Delavirdine (Rescriptor) is approved for the treatment of HIV-1 infection in adults and adolescents over age 16 as part of a combination therapy. Rash accompanied by pruritus is the most frequent adverse effect of this agent however, it usually resolves within several weeks of treatment. Severe skin reactions are rare. Headache, nausea, vomiting, diarrhea, fatigue, and elevated hepatic enzymes also may be associated with delavirdine administration. 

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