Mono-oxygenase

Other experiments with Gibberellafujikuroi the fungus that produces gibbereUin, indicate that GA production is blocked by BAS 111. Very detailed and carehil experiments conducted with enzymes in ceU-free systems strongly support this mode of action, ie, using /-kaurene oxidase and cinnamate 4-mono-oxygenase isolated from pea apices and soybean suspension cells, and avanone-2-hydtoxylase and dibydroxypterocarpane 6-hydtoxylase from soybean suspension cells (31). [Pg.427]

The lower than expected yields can be explained by the nature of methane oxidation to methanol in these bacteria. This reaction, catalysed by methane mono-oxygenase, is a net consumer of reducing equivalents (NADH), which would otherwise be directed to ATP generation and biosynthesis. In simple terms the oxidation of methane to methanol consumes energy, lowering the yield. [Pg.89]

P450 Mono-oxygenase System Reactive Oxygene Species Oxidative Stress Vitamin C Vitamin E... [Pg.162]

Targeted Cancer Therapy P450 Mono-Oxygenase System... [Pg.221]

P450 Mono-Oxygenase System P450 Enzymes... [Pg.222]

Prostanoids Leukotrienes Cuclooxy genases p450 Mono-oxygenase System... [Pg.457]

Peroxisome Proliferator-Activated Receptors (PPARs) P450 Mono-oxygenase System Nuclear Receptors Orphan Receptors... [Pg.914]

Cytochrome P450 (CYP) Cytochrome P450 isozymes Cytochrome P450 mono-oxygenases Mixed function oxidases... [Pg.921]

Cytochrome P450 (CYP) mono-oxygenases, also called mixed function oxidases, are versatile hemoprotein enzymes that catalyze the cleavage of molecular oxygen to incoiporate one oxygen atom into a substrate molecule and one atom into water [1]. The general stoichiometry of the reaction is as follows (S-H, substrate) ... [Pg.921]

P450 Mono-oxygenase System. Figure 1 (a) Components of the microsomal P450 mono-oxygenase system, (b) Components of the mitochondrial P450 mono-oxygenase system. [Pg.922]

P450 Mono-oxygenase System. Table 1 Overview of the cytochrome P450 superfamily in humans... [Pg.924]

P450 Mono-oxygenase System P-type ATPase(s)... [Pg.1499]

The primary physiological role of the P450 family is that of a mono-oxygenase. The catalytic reaction can be summarized as... [Pg.166]

FIG. 21 Schematic diagram of cytochrome P450 mono-oxygenase reaction with substrate RH and product ROH. [Pg.167]

The major mono oxygenases in the endoplasmic reticulum are cytochrome P450s—so named because the enzyme was discovered when it was noted that preparations of microsomes that had been chemically reduced and then exposed to carbon monoxide exhibited a distinct peak at 450 nm. Among reasons that this enzyme is important is the fact that approximately 50% of the drugs humans ingest are metabolized by isoforms of cytochrome P450 these enzymes also act on various carcinogens and pollutants. [Pg.627]

Fig. 25.8 (a) Normal metabolism, in which phenylalanine is converted by phenylalanine 4-mono-oxygenase to tyrosine, (b) Phenylketonuria, in which there is a transamination reaction between phenylalanine and a-ketoglutaric acid. Phenylalanine 4-mono-oxygenase is absent in about 1 in every 10000 human beings because of a recessive mutant gene. [Pg.483]

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