Orientation strategy

Figure 1. Schematic illustrations of a functionality-oriented strategy in applied catalysis research (panel A) and a catalytic insight-driven strategy in fundamental model studies (panel B).

Lu K, Luo TP, Xiang Z, You ZJ, Eathi R, Chen JH, Yang Z (2005) A concise and diversity-oriented strategy for the synthesis of benzofurans and indoles via Ugi and Diels-Alder reactions. J Comb Chem 7 958-967... 

As a further activity the Austrian Federal Ministry of Agriculture, Forestry, Environment and Water Management (BMLFUW) in co-operation with the OECD organised an international conference in Vienna in November 2003, which was called "Experiences and Perspectives of Service-oriented Strategies in the Chemicals Industry and Related Areas". The conference was attended by around 100 participants from 16 countries. The conference gave an excellent overview about international approaches how to introduce service elements into the chemical business. The participants comprised representatives from authorities, the chemical industry, in particular down stream users, process engineers and economists along with representatives from academia. 

In co-operation with the OECD the Austrian Federal Ministry of Agriculture, Forestry, Environment and Water Management (BMLFUW) hosted the international conference Experiences and Perspectives of Service-oriented Strategies in the Chemicals Industry and Related Areas" in Vienna in November 2003. The conference concluded ... 

OECD, Organisation for Economic Co-operation and Development, Environment Directorate, 13-Dec-2004, ENV/JM/MONO(2004)28/PART1, Series on Risk Management No 17, "Workshop on experiences and perspectives of service-oriented strategies in the chemicals industry and related areas", Vienna, Austria, 13-14 November 2003, Part I Summary and conclusions... 

In term of diversity-oriented strategies, multicomponent reactions (MCR) represent an attractive and rapid access to libraries of macrocycles inspired by biologically active natural products. Combined with Passerini and Ugi reactions, M-RCM has already shown promising synthetic potential, as illustrated by the pioneering work of Domling and coworkers [46]. Condensation of isocyanide 69 with carboxylic acid 70 in the presence of paraformaldehyde leads to bis-olefin 71, which is subsequently submitted to RCM in the presence of G1 and titanium isopropoxide to give the 22-membered macrocycle 72 (Scheme 2.27). 

B. Chemistry-Guided Versus Technique-Oriented Strategy... 

Scheme 20.18 Regio-orientation strategy using boronate linkers attached to PS.

Coupled process modeling is requested in the DECOVALEX international project in order to study the influence of process interactions. Therefore a process oriented strategy and the implementation of a control concept was demanded, which allows the selective activation of processes. Furthermore, it was necessary to have selectable couplings in order to perform sensitivity analyses. Thus, the importance of different kinds of... 

TOMBA, A.M., KELLER, T.A., MOORE, P.A., 2001. Foraging in complex odor landscapes chemical orientation strategies during stimulation by conflicting chemical cues. J. N. Amer. BenthoL Soc., 2001, 20, 211-222. 

FIGURE 7.7 Antibody orientation strategy for biochip development. Random immobilization by adsorption or covalent attachment leads to nonaccessible (A) or only partially accessible (B) antigen-binding domains. In (C) correct orientation of antibody will give maximum activity and this is achieved using a linker molecule (e.g., Protein A). 

Waterborne Chemical Communication Stimulus Dispersal Dynamics and Orientation Strategies in Crustaceans... 

The recent availability of detailed data on chemical plume signal structure, and the relationship of this structure to the fluid environment, has lead to tractable and testable hypotheses on presumptive orientation strategies. These hypotheses center on the availability of spatial vs. temporal information, the role of accessory... 

Corporate diversity leaders must innovate and enhance their work to be effective and to create sustainable, results-oriented strategies and tactics. We must always be innovating if we are to create inclusive organizations that work for all employees. I conclude with ten recommendations for moving forward. 

Equally important is the prediction of spectral parameters in order to rank the candidates of the structure generator. Chemical shifts and couphng constants may serve as an example where substructure oriented strategies lead to an acceptable estimate of the spectral curve. 

When skeletal bonds to groups R and R are to be made in the vicinity of a carbon-carbon double bond, substitution of allylic acetates by organocuprates or by malonates (Pd(O)-catalyzed) comes to mind. Alternatively, when R and R are to be introduced as electrophiles (a-synthons), one considers the Lewis acid catalyzed substitution of allylsilanes or allylstannanes. The incorporation of a branched methallyl or isoprene moiety in this manner represents a standard example of a building block oriented strategy in synthesis [28] (Scheme 3.18). 

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