Optical breast imaging

Ntziachristos, N. and Chance, B. 2001, Breast imaging technology Probing physiology and molecular function using optical imaging- applications to breast cancer. Breast Cancer Research 3, 41-46... 

An optical patient interface is shown right. The system can be used for brain and breast imaging. Applications are described in [222, 223, 224, 225,234, 444]. 

Optical mammography Brain imaging Sequential and/or parallel detection of light at selected points reconstruction of 2D, 3D images Reflected or Breast tumours transmitted light, fluorescence Brain perfusion, stroke... 

The system includes various software packages for different applications (De Cresce, 1986). It allows immunostained histological sections to be represented as digitized images from which the optical densities of the DAB reaction product over a specific cell part or component (e.g., nucleus) can be quantitated. Bacus et al. (1988) have successfully quantified the estrogen receptor content in human breast tumors. The data showed excellent sensitivity and specificity. 

Heffer E, Pera V, Schutz O, Siehold H, Fantini S. Near-infrared imaging of the human breast complementing hemoglobin concentration maps with oxygenation images. Journal of Biomedical Optics 2004, 9, 1152-1160. 

Figure 3.100. TPLSM demonstrates the uptake of nanoclinics by cancer cells. The particles are incubated with adherent MCF-7 cells (breast carcinoma) at room temperature, (a) Particle accumulation on and inside the cell versus incubation time (images recorded after 3, 15, and 27 minutes incubation), (b, c) Single optical sections of cells after 15 minutes of incubation. The arrow shows accumulation of nanoclinics on and inside the cell (b transmission, c fluorescence). (From Ref. [192] with permission of Kluwer Academic Publishers.)...

The Fischer device was a slot-scanning system in which a 14-mm wide fan-beam scanned across the breast over about 5 s. The image was collected by a rectangular detector consisting of a Csl crystal coupled via a fiber-optic bundle to a linear array of charge-coupled... 

Herranz, M., Ruibal, A. Optical imaging in breast cancer diagnosis the next evolution. Journal of Oncology (2012). Article ID 863747... 

A. L. Oldenburg et al.. Imaging gold nanorods in excised human breast carcinoma by spectroscopic optical coherence tomography. Journal of Materials Chemistry, 19(35), 6407-6411 (2009). 

Mammograms are uncomfortable and embarrassing for women. NIR imaging [84] and an optical biopsy [85] may be performed. NIR radiation has been suggested as an alternative to both x-rays and physical, invasive biopsies. Breast cancer is one of the leading causes of death and disfigurement in woman, it is best detected early [85]. 

---