Brain perfusion

Holman BL, Carvalho PA, Mendelson J, er al Brain perfusion is abnormal in cocaine-dependent polydrug users a study using technetium-99m-HMPAO and ASPECT. J Nucl Med 32 1206-1210, 1991... 

Review of postcontrast CTA source images might provide a good estimate of whole-brain perfusion." If time allows, MR or CT perfusion maps are obtained to characterize more accurately the ischemic penumbra." Careful but expedited preprocedural analysis of the CTA, done in parallel with transport of the patient to the treatment area, may be extremely helpful in establishing the presence of anatomic variants (e.g., bovine aortic arch) or pathological states (e.g., vessel origin or carotid bifurcation disease) prior to the catheterization procedure. 

Dagenais C, Rousselle C, Pollack GM, Scherrmann JM. Development of an in situ mouse brain perfusion model and its application to mdrla P-glycoprotein-defi-cient mice. J Cereb Blood Flow Metab 2000 20 381-386. 

Alyautdin RN, Tezikov EB, Ramge P, Kharkevich DA, Begley DJ, Kreuter J (1998) Significant entry of tubocurarine into the brain of rats by adsorption to polysorbate 80-coated polybutylcyanoacrylate nanoparticles an in situ brain perfusion study. J Microencapsul 15 67-74. 

Murakami H, Takanaga H, Matsuo H, Ohtani H, Sawada Y (2000) Comparison of blood-brain barrier permeability in mice and rats using in situ brain perfusion technique. Am J Physiol 279 H1022-H 1028. 

Optical mammography Brain imaging Sequential and/or parallel detection of light at selected points reconstruction of 2D, 3D images Reflected or Breast tumours transmitted light, fluorescence Brain perfusion, stroke... 

O Leary, D.S. et al., Effects of smoking marijuana on brain perfusion and cognition, Neumpsycho-pharmacology, 26, 802, 2002. 

Both chelates have been launched as extracellular contrast agents using doses up to 3 mmol/kg body weight. Both can be formulated as 1.0 molar aqueous solutions with acceptable viscosity (Table 2). These highly concentrated agents are useful in fast dynamic studies such as brain perfusion and fast magnetic resonance angiography (MRA). 

These highly concentrated solutions are useful in fast dynamic studies such as brain perfusion and in magnetic resonance angiography (MRA) [56,57]. 

Preston, J.E., H. Al-Saraff, and M.B. Segal. 1995. Permeability of the developing blood-brain barrier to 14C-mannitol using the rat in situ brain perfusion technique. Brain Res Dev Brain Res 87 69. 

Some efforts have been made to determine the effect P-gp has on its substrates by use of in situ perfusion methods, including intestinal perfusion, liver perfusion, kidney perfusion, and brain perfusion. These experiments allow the researcher to study the transport of compounds in a physiologically relevant environment in which the integrity of the organ is preserved with regards to cell polarity and representation of all cell types seen in the organ. Furthermore, the reduction in complexity of in situ models versus in vivo studies facilitates the conduct of complex studies and allows more definitive conclusions to be made regarding the role P-gp may play in disposition. 

Smith QR. Brain perfusion systems for studies of drug uptake and metabolism in the central nervous system. In Borchardt RT, ed. Models for Assessing Drug Absorption and Metabolism. New York Plenum Press, 1996. 

Smith QR, Takasato Y. Kinetics of amino acid transport at the blood-brain barrier studied using an in situ brain perfusion technique. Ann N Y Acad Sci 1986 481 186-201. 

Takasato Y, Rapoport SI, Smith QR. An in situ brain perfusion technique to study cerebrovascular transport in the rat. Am J Physiol 1984 247(3 pt 2) H484-H493. 

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