Oestrogens

It has oestrogenic properties (see oestradiol) and is used for the same purposes as stilboes-trol. ... [Pg.136]

An oestrogen found in the urine of pregnant mares. It is not so physiologically active as equilin. [Pg.160]

An oestrogen present in the urine of pregnant women. It possesses female sex hormone activity but is not as active as oestrone. [Pg.286]

C,flH2o02- White crystals, m.p. 168-171 °C. Prepared from deoxyanisoin by ethylation, conversion to the alcohol, dehydration and demethylation. It is an oestrogenic substance which is highly active when administered orally. It is used for treating menopausal symptoms, for the suppression of lactation and for treatment of cancer of the prostate. [Pg.372]

Institute for Environment and Health Assessment Al, Environmental Oestrogens Consequences to Human Health and Wildlife, lEH, Leicester, 1995. [Pg.1]

It is not certain that all the effects of DES can be ascribed to its oestrogenic activity (that is to say, directly related to its ability to bind to the oestrogen receptor), but it would appear from experience with this compound that rodent assays are able to detect the relevant toxicological effects. What then was the... [Pg.2]

C. Desbrow, E. Routledge, D. Sheehan, M. Waldock and J. Sumpter, in The Identification and Assessment of Oestrogen Substances in Sewage Treatmen t Works Effinents, Environment Agency, Bristol, 1996. [Pg.10]

More subtle modes of action are also possible since the response to hormone receptor binding is complex and could be affected by chemical interference with receptor-related proteins, DNA methylation or histone acetylation. Dioxin (TCDD), for example, reduces the ability of the oestrogen-receptor complex to bind to the oestrogen response element of DNA, reducing gene transcription. ... [Pg.12]

The responsiveness of a tissue to a hormone depends on the density of receptors within its component cells. The number of receptors is determined by their rate of synthesis and catabolism, which is itself controlled by complex feedback mechanisms involving hormone action. Some chemicals are known to interfere with this regulation. For example, TCDD can act to increase or decrease the expression of the oestrogen receptor. ... [Pg.13]

Produced by fungi which can contaminate crops. Some, such as zearalenone, are oestrogenic DDT, lindane and beta-HCH are common, persistent environmental pollutants Widespread, persistent environmental pollutants... [Pg.14]

Meat, dairy products and eggs contain low levels of natural hormones, including oestrogens, progesterone and testosterone, possibly enhanced by the use of hormones for veterinary purposes or as growth enhancers. " ... [Pg.14]

Drugs with endocrinological functions or side-effects are common, but oestrogenic hormones in oral contraceptives are particularly widely used. Pharmaceuticals and their metabolites eventually find their way into the environment, predominantly via excretion into sewage. ... [Pg.15]

ECETOC, Document No. 33 Environmental Oestrogens A C/ mpendinm of Test Methods, ECETOC, Brussels, 1996. [Pg.16]

Oestrogen receptor binding/Reporter gene assay. [Pg.18]

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