Conjugated equine oestrogen

V.a.1.1. Oral HRT preparations. For oral therapy, there is a choice between conjugated equine oestrogens purified from urine, synthetic oestro-gens such as ethinyloestradiol and tibolone, and oestradiol itself. In women with an intact uterus, the oestrogen should normally be given in conjunction with a progestagen in order to protect the endometrium from unopposed oestrogenic stimulation. 

Register TC, Cann JA, Kaplan JR et al. Effects of soy isoflavones and conjugated equine oestrogens on inflammatory markers in atherosclerotic, ovariectomized monkeys. J. Clin. Endocrinol Metab. 90, 1734-1740, 2005. 

Combined oral contraceptives (see Oral contraceptives, combined) Conjugated equine oestrogens... 

Ethinyloestradiol, or its methylated derivative mestranol, is a satisfactory first choice for pharmacotherapy. The weaker endogenous oestrogens, oestradiol, oestrone or the conjugated equine oestrogens are preferable for physiological replacement. It remains uncertain whether all oestrogens have exactly similar hormonal and nonhormonal effects, including adverse effects. 

Other oestrogens which have been used to treat prostatic cancer have failed to receive universal acceptance. Polyoestradiol phosphate (Estradurin), a long-acting oestrogenic preparation given intramuscularly, is well used in Scandinavia but only weakly suppresses pituitary activity [42] and neither Premarin, a mixture of conjugated equine oestrogens (2.5 mg, t.d.s.), nor ethynyloestradiol (0.15-1.0 mg/day), has been universally accepted. 

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