Apoptosis, neutrophils

Niwa, M., Kara, A., Kanamori, Y, Matsuno, H., Kozawa, O., Yoshimi, N., Mori, H., and Uematsu, T., Inhibition of tumor necrosis factor-ct induced neutrophil apoptosis by cyclic AMP Involvement of caspase cascade. Eur. J. Pharmacol. 371, 59-67 (1999). 

Yang KY, Arcaroli J, Kupfner J, Pitts TM, Park JS, Strasshiem D, Perng RP, Abraham E (2003) Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis. Cell Signal... 

Altznauer, F., Conus, S., Cavalli, A., Folkers, G. and Simon, H. U., 2004, Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis. J Biol Chem 279, 5947-57. Antonsson, B. and Martinou, J. C., 2000, The Bcl-2 protein family. Exp Cell Res 256, 50-7. Benali-Furet, N. L., Chami, M., Houel, L., De Giorgi, F., Vernejoul, F., Lagorce, D., Buscail, L., Bartenschlager, R., Ichas, F., Rizzuto, R. and Paterlini-Brechot, P., 2005, Hepatitis C virus core... 

Webb PR, Wang KQ, Scheel-Toellner D, Pongracz J, Salmon M, Lord JM. Regulation of neutrophil apoptosis A role for protein kinase C and phosphatidylinositol-3-kinase. Apoptosis 2000 5 451-458. 

Grigg JM, Savill JS, Sarraf C, Haslett C, Silverman M. Neutrophil apoptosis and clearance from neonatal lung. Lancet 1991 338 720-722. 

Renshaw SA, Parmar JS, Singleton V, Rowe SJ, Dockrell DH, Dower SK, et al. Acceleration of human neutrophil apoptosis by TRAIL. J Immunol 2003 170 1027-1033. 

Intracellular mechanisms governing apoptosis are as yet poorly understood. However, there are indications that internal controls in granulocytes may differ from lymphoid cells. In thymocytes, elevation of intracellular calcium concentration ([Ca " ] ) by calcium ionophores induces apoptosis, and apoptosis induced by other stimuli, such as glucocorticoids, is associated with rises in [Ca " ] (McConkey et al., 1989). However, in neutrophils spontaneously undergoing apoptosis, there were no such rises in [Ca " ] , and agents increasing [Ca " ] caused dramatic slowing of neutrophil apoptosis without... 

Grigg, J.M., Savill, J.S., Sarraf, C., Haslett, C. and Silverman, M. Neutrophil apoptosis and clearance from neonatal lungs. Lancet 338, 720-722. 

Seumois, G., Fillet, M., Gillet, L., Faccinetto, C., Desmet, C., Francois, C., Dewals, B., Oury, C., Vanderplasschen, A., Lekeux, P., and Bureau, F., De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosis, J Leukoc Biol, 81 (2007) 1477-1486. 

Williams DP, Pirmohamed M, Naisbitt DJ, Uetrecht JP, Park BK (2000) Induction of metabolism-dependent and -independent neutrophil apoptosis by clozapine. Mol Pharmacol 58 207-216 Wolf B, Conradty M, Grohmann R, Ruther E, Witzgall H, Londong V (1989) A case of immune complex hemolytic anemia, thrombocytopenia, and acute renal failure associated with doxepin... 

A singular characteristic of neutrophils is that they undergo spontaneous apoptosis. Whereas this process and its modulation by various agents have been extensively studied in neutrophils [as recently reviewed in 100 and in this book], the molecular events involved remain poorly understood. Given its central role in the induction of various antiapoptotic proteins, the NF-kB pathway could represent an important mechanism whereby neutrophil apoptosis is regulated, as described in many other cellular models [reviewed in 101]. 

Nolan B, Kim R, Duffy A, Sheth K, De M, Miller C, Chari R, Bankey P Inhibited neutrophil apoptosis Proteasome dependent NF-kB translocation is required forTRAF-1 synthesis. Shock 2000 14 290-294. 

Niwa M, Kara A, Kanamori Y, Hatakeyama D, Saio M, Takami T, Matsuno H, Kozawa O, Uematsu T Nuclear factor-KB activates dual inhibition sites in the regulation of tumor necrosis factor-a-induced neutrophil apoptosis. Eur J Pharmacol 2000 407 211-219. 

Akgul C, Moulding DA, Edwards SW Molecular control of neutrophil apoptosis. FEBS Lett 2001 487 318-322. 

Keel M, Ungethum U, Steckholzer U, Niederer E, Hartung T, Trentz O, Ertel W Interleukin 10 counterregulates proinflammatory cytokine-induced inhibition of neutrophil apoptosis during severe sepsis. Blood 1997 90 3356-3363. 

Biffl WL, Moore EE, Moore FA, Barnett CC, Carl VS, Peterson VM Interleukin-6 delays neutrophil apoptosis. Arch Surg 1996 131 24-30. 

Coxon A, Tang T, Mayadas N Cytokine-activated endothelial cells delay neutrophil apoptosis in vitro A role of granulocyte/macrophage colony-stimulating factor. J Exp Med 1999 190 923-933. Whyte M, Renshaw S, Lawson R, Bingle C Apoptosis and the regulation of neutrophil lifespan. Biochem Soc Trans 1999 27 802-807. 

Simon HU Regulation of eosinophil and neutrophil apoptosis Similarities and differences. Immunol Rev 2001 179 156-162. 

Whyte MK, Savill J, Meagher JC, Lee A, Haslett C Coupling of neutrophil apoptosis to recognition by macrophages Coordinated acceleration by protein synthesis inhibitors. J Leukoc Biol 1997 62 195-202. 

Ottonello L, Frumento G, Arduino N, Bertolotto M, Mancini M, Sottofattori E, Dallegri F, Cutolo M Delayed neutrophil apoptosis induced by synovial fluid in rheumatoid arthritis Role of cytokines, estrogens, and adenosine. Ann NY Acad Sci 2002 966 226-231. 

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