Trifluoromethylbenzoic acid

FLUORINECOMPOUNDS,ORGANIC - FLUORINATED AROMATIC COMPOUNDS] (Volll) o-Trifluoromethylbenzoic acid [433-97-6]... 

Treatment ot I,l,3,3-tetrafluoro-l,3-dihydroisobenzofuran with anhydrous hydrogen fluoride, followed by hydrolysis of the intermediate acid fluoride, gives a high yield of 2-trifluoromethylbenzoic acid [4] (equation 4). 

A broad-spectrum grass and broadleaf corn herbicide Regulated metabolites in groundwater include the parent, isoxaflutole (RPA 201772), and its metabolites RPA 202248 [2-cyclopropylcarbonyl-3-(2-methylsulfonyl-4-trifluoromethylphenyl)-3-oxopropanenitrile] and RPA 203328 (2-methanesulfonyl-4-trifluoromethylbenzoic acid)... 

One fluorine atom is leaving as a fluoride ion, and the exocylic double bond to the difluoromethylene group is attacked by a hydroxide anion. Elimination of hydrogen fluoride gives an acyl fluoride that is readily hydrolyzed to the final product, 2-amino-4-trifluoromethylbenzoic acid (K) [59],... 

Triethylene thiophosphoramide, 1020 Triflumethazine, 629 Trifluomeprazine, 1043 Trifluomeprazine maleate, 1043 Trifluoperazine, 1043 Trifluoperazine hydrochloride, 1044 Trifluoperazine sulphoxide, 1044 Trifluoroacetic acid, 649 Trifluoroacetic anhydride, 188, 189 Trifluoromethylbenzoic acid, 614 Trifluoromethylhippuric acid, 614 Trifluoromethylhydrothiazide, 667... 

Cathodic addition of trichloromethylbenzene to ketones gives or.yS-unsaturated ketones [139]. Methyl esters of trifluoromethylbenzoic acid can be defluorinated by reduction at lead cathodes in MeOH [140,141]. Fry and Touster [142] have reduced a benzal halide at stainless steel in DMF containing trimethylchlorosilane to synthesize both the (cy-halo-benzyl)silane and the benzal disilane. 

Hydroxybenzoic acids—see also Dihydroxybenzoic acids, 2-Hydroxy-4-trifluoromethylbenzoic acid, 3,4,5-Trihydroxybenzoic acid... 

Hydroxytetrahns, reactions of 652 2-Hydroxy-4-trifluoromethylbenzoic acid, irradiation of 1079 8-Hydroxy-l, 3,6-tris(iV,iV-... 

Bosca, F., Cuquerella, M.C., Marin, M.L., and Miranda, M.A., 2001, Photochemistry of 2-hydroxy-4-trifluoromethylbenzoic acid, major metabolite of the photosensible platelet antiaggregant drug triflunisal, Photochem. Photobiol. 73, 463-468. 

Bayon Y, Alonso A, Crespo MS. 4-Trifluoromethyl derivatives of salicylate, triflusal and its main metabolite 2-hydroxy-4-trifluoromethylbenzoic acid, are potent inhibitor of nuclear factor kB activation. Br J Pharmacol 1999 126 1359-1466. 

The oxidative carbonylation of benzotrifluoride to form trifluoromethylbenzoic acids has been described by Bell and Zakzeski [38]. By using a Pd(II) catalyst in combination with a carboxylic acid, ammonium metavanadate, CO, and O2, trifluoromethylbenzoic acid was achieved in good selectivity. Shi and his colleagues performed LiCl-promoted Pd(II)-catalyzed oxidative carbonylation of A(A-dim-ethylbenzylamines [39]. This reaction is highly regioselective and the product can be further transformed into ortho-methyl benzoate under mild conditions. 

---