Nitric oxide actions

Horn T, Smith PM, McLaughlin BE, et al Nitric oxide actions in paraventricular nucleus cardiovascular and neurochemical implications. Am J Physiol 266 R306— R313,1994... 

Physiological sites proposed for nitric oxide action include the immune system, where nitric oxide acts as a cytostatic agent, is tumoricidal, and can inhibit viral replication. In the cardiovascular system, nitric oxide is the biological mediator of vasodilator responses to agents such as acetylcholine and bradykinin, which act as receptors on endothelial cells to activate NOS and stimulate nitric oxide production. Diffusible nitric oxide then activates guanylate cyclase in vascular smooth muscle cells, leading to the production of cyclic guano-sine monophosphate (GMP) and vasodilation. In the brain, stimulation of A-methyl-o-aspartate receptors on... 

Schuman EM, Meffert MK, Schulman H, Madison DV (1994) An ADP-ribosyltransferase as a potential target for nitric oxide action in hippocampal long-term potentiation. Proc Nad Acad Sci USA 91 11958-62... 

Sun X, Kaltenbronn KM, Steinberg TH et al (2005) RGS2 is a mediator of nitric oxide action on blood pressure and vasoconstrictor signaling. Mol Pharmacol 67 631-639... 

Ignarro, L. J. (1989b). Endothelium-derived nitric oxide Actions and properties. FASEB J. 3, 31-36. 

Bonartsev, A. R et al. A new in vivo model of prolonged local nitric oxide action on arteries on basis of biocompatible polymer. The J. Clinical Hypertension. 2007, Suppl. A, 9(3 , Al 52(c). 

In a vacuum, uncoated molybdenum metal has an unlimited life at high temperatures. This is also tme under the vacuum-like conditions of outer space. Pure hydrogen, argon, and hehum atmospheres are completely inert to molybdenum at all temperatures, whereas water vapor, sulfur dioxide, and nitrous and nitric oxides have an oxidizing action at elevated temperatures. Molybdenum is relatively inert to carbon dioxide, ammonia, and nitrogen atmospheres up to about 1100°C a superficial nitride film may be formed at higher temperatures in the latter two gases. Hydrocarbons and carbon monoxide may carburize molybdenum at temperatures above 1100°C. 

Nitric Oxide. Nitric oxide [10102-43-9] NO, is a ubiquitous intracellular and intercellular messenger serving a variety of functions including vasodilation, cytotoxicity, neurotransmission, and neuromodulation (9). NO is a paramagnetic diatomic molecule that readily diffuses through aqueous and hpid compartments. Its locus of action is dictated by its chemical reactivity and the local environment. NO represents the first identified member of a series of gaseous second messengers that also includes CO. 

Sodium nitrite hy action of nitric oxide and oxygen on aqueous sodium carbonate... 

Sodium hypochlorite hy action of chlorine on aqueous sodium hydroxide Ammonium nitrate hy action of ammonia on aqueous nitric acid Nitric acid hy absorption of nitric oxide in water... 

The reason that Hb doesn t block the action of NO is due to a unique interaction between Cys93/3 of Hb and NO recently described by Li Jia, Celia and Joseph Bonaventura, andjohnathan Stamler at Duke University. Nitric oxide reacts with the sulfhydryl group of Cys93/3, forming an S-nitroso derivative ... 

Apelins and the Apelin Receptor. Figure 3 Scheme illustrating the hypothesised mechanisms of control of human (a) vasculartone and (b) cardiac contractility by apelin peptides ( ). In the vasculature, apelins (released via the small vesicles of the constitutive pathway) may act directly to activate apelin receptors on the underlying smooth muscle to produce vasoconstriction. This response may be modified by apelin peptides feeding back onto apelin receptors on endothelial cells to stimulate the release of dilators, such as nitric oxide. In heart, apelin peptides, released from endocardial endothelial cells, activate apelin receptors on cardiomyocytes to elicit positive inotropic actions. 

Synthesized by soluble guanylyl cyclase and particulate guanylyl cyclase from guanosine triphosphate (GTP). Nitric oxide activates soluble guanylyl cyclase to enhance cyclic GMP production that contributes to various NO actions. Cyclic GMP is hydrolyzed by phosphodiesterases. Cyclic GMP binds to and activates cGMP-dependent protein kinase, phosphodiesterases, and Cyclic Nucleotide-regulated Cation Channels. 

MEDINA in an acronym for MEthylene DINtrA-mine. In earlier literature it was called MEDNA (Ref 2), the latter name later used for the isomeric compd me thylenedi-isonitramine which was obtained by the action of nitric oxide on acet (Beil 1, 592) (See under MEDNA in this... 

Histories . The Na salt was first isolated by the reaction of nitric oxide on acet (Ref 2) later the same worker found that the action of nitric oxide and Na hydroxide on any compd contg the acetyl group would give Na MEDNA [compds treated were mesityl oxide, methylisopropyl ketone, acetophenone, and ethyl dimethyl-... 

MEDNA salts could be obtained by prolonged -contact of nitric oxide with Na ethoxide or K ethoxide (Ref 4). The Ba salt was obtained by the action of nitric oxide on Na isopropoxide or Na 1 -phenylethoxide followed by the addn of Ba chloride- soln (Ref 6). The UV spectra were used to distinguish between saits of MEDNA and MEDINA and to prove the structure of each (Ref 8)... 

Quite unexpectedly, EDRF was found to be the gas nitric oxide (NO). NO is formed by the action of the enzyme NO synthase, which is cytosolic. The endothe-hal and neuronal forms of NO synthase are activated by Ca + (Table 49-8). The substrate is arginine, and the products are citmUine and NO ... 

Mayer B, Hemmens B Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem Sci 1998 22 477. 

Figure 13.9 The production and actions of nitric oxide (NO). The influx of calcium through either calcium channels or NMDA receptors triggers NOS to convert L-arginine to NO. L-NAME and 7-NI inhibit this process. NO, once produced, can diffuse in a sphere and then can activate guanylate cyclase...

Clancy, R.M., Leszczynska-Piziak, J. and Abramason, S.B. (1992). Nitric oxide inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase. J. Clin. Invest. 90, 1116-1121. 

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