Novel Bioreactors

Stuckey, D.C., Caridis, K.A., Leak, D.J., Design of a novel bioreactor with cell recycle for continuous biotransformation and product extraction, Proc. 3rd Asia Pacific Biochemical Eng. Conf, Singapore, pp.315-317, 1994. 

Bramble, J. L., Graves, D. J., and Brodelius, P., Plant Cell Culture Using a Novel Bioreactor The Magnetically Stabilized Fluidized Bed, Biotechnol. Prog.,... 

The development of novel bioreactors and bioreactor operating strategies has the potential to improve the performance of cell culture systems. Some progress has been made in this area to enhance foreign protein production in plant tissue culture. 

Mezohegyi G, Bengoa C, Stuber F et al (2008) Novel bioreactor design for decolourisation of azo dye effluents. Chem Eng J 143 293-298... 

All novel bioreactors attempt to increase productivity by increasing yeast cell concentration or by reducing ethanol inhibition and much work has been reported on ethanol production in fluidized beds by Bauer, Hayes, Moebus, Rottenbacher, Teuber and their co-workers aqueous glucose solutions can be atomised within a bed of yeast particles with the latent heat for vaporisation of both ethanol and... 

A novel bioreactor, especially designed to work with two liquid phases, is the liquid-impelled loop reactor (Figme 11.10), in which the advantages of air lifts and... 

The fifth paper, "A Separative Bioreactor Direct Product Capture and pH Control," presented by Seth Snyder of the Argonne National Laboratory, reviewed development and performance of a novel bioreactor incorporating electrodeionization to simultaneously produce and separate products from both enzymatic and microbially mediated reactions. The sixth paper, " Optimization of Xylose Fermentation in Spent Sulfite Liquor by Saccharomyces cerevisiae 259ST," presented by Steven Helle of the University of British Columbia, provided an overview of an approach to fermentation optimization utilized to identify key process variables limiting use of the SSL for commercial ethanol production. 

The yield of secondary metabolites in a large-scale fermenter typically ranges from 0.1 to lOg/L of broth. Such poor yield leads to cumbersome and expensive processes for both product separation and broth disposal. Within the last decade, several novel bioreactors have been developed for the intensification of fermentation processes. Examples include a centrifugal bioreactor, a rotating packed bed fermenter, and a sonobioreactor. Most of these, however, are yet to be implemented on a production scale because they generally lack practicality and well-defined scale-up criteria. 

Palazon, J., Mallol, A., Eibl, R., Lettenbauer, C., Cusido, R. M., and Pinol, M. T. (2003) Growth and ginsenoside production in hairy root cultures of Panax ginseng using a novel bioreactor. PlantaMed. 69, 344-349. 

Novel bioreactors can be represented by many different designs and variations, but the most novel and promising approach may turn out to be miniaturized reactors. 

TABLE 12.2 Summary of Less Important and Novel Bioreactors... 

Son SH, Choi SM, Lee YH, Choi KB, Yun SR, Kim JK, Park HJ, Kwon OW, Noh EW, Seon JH, Park YG. Large-scale growth and taxane production in cell cultures of Taxus cuspidata (Japanese Yew) using a novel bioreactor. Plant Cell Rep. 2000 19 628-633. 

In the UK, Heriot-Watt University has been studying marine bioprocess intensification, in particular using novel bioreactors (Wright et al., 1999). With optimisation and conversion of current technologies these have the potential to yield more efficient units. 

Birla, R, K., Y. C. Huang, and R. G. Dennis. 2007. Development of a novel bioreactor for the mechanical loading of tissue-engineered heart muscle. Tissue Eng 13(9) 2239-48. 

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