Novel bioreactor designs

Mezohegyi G, Bengoa C, Stuber F et al (2008) Novel bioreactor design for decolourisation of azo dye effluents. Chem Eng J 143 293-298... 

Stuckey, D.C., Caridis, K.A., Leak, D.J., Design of a novel bioreactor with cell recycle for continuous biotransformation and product extraction, Proc. 3rd Asia Pacific Biochemical Eng. Conf, Singapore, pp.315-317, 1994. 

A novel bioreactor, especially designed to work with two liquid phases, is the liquid-impelled loop reactor (Figme 11.10), in which the advantages of air lifts and... 

Novel bioreactors can be represented by many different designs and variations, but the most novel and promising approach may turn out to be miniaturized reactors. 

Wolfrum E.J. and Watt A.S. (2001) Bioreactor design studies for a novel hydrogen-producing bacterium. Proceedings of the 2001 DOE Hydrogen Program Review, NREL/CP-570-30535. 

In the literature many examples of more or less exotic bioreactors can be found. Few actually are applied, outside the laboratory. Here two novel designs, the membrane and the liquid-impelled loop reactor, are discussed briefly. These two reactors are simple to use and, to a certain extent, liable to scale-up and both integrate the actual biocatalysis with part of the down-stream processing. 

Recently, Wang and Zhong successfully designed a novel centrifugation impeller bioreactor (Fig. 3) for shear-sensitive cell systems [35, 36]. They proved... 

General design considerations for mechanically agitated gas-liquid and gas-liquid-solid mechanically agitated reactors described earlier in Sections II and III are applicable here. In this section, however, we evaluate additional design considerations that are specific to bioreactors. Novel reactors to overcome specific needs of biological processes are also evaluated in this section. The characteristics of the bioreactors and other chemical/ petrochemical gas-liquid and slurry reactors are compared in Table XX. 

Furthermore, in most cases, the 3D architecture of the support and cell distribution is also important in cell viability and cell function. The cell support system developed by Akay elalS ° is designed to address these issues. In this study, we use the technique of Akay and co-workerst ° to obtain micro-cellular polymers of controlled microarchitecture to immobilize bacteria employing a novel seeding technique. Operated as a flow-through system in the degradation of phenol in water, this micro-bioreactor is shown to represent a clear BI. 

Novel mechanical or bubble-induced flow designs are not trendsetters nor do they solve many of the and gas-liquid mass transfer problems. Miniaturized reactors, however, could decrease process design and implementation signiflcantly. The numbering-up method for these reactors reduces the time and amount of work necessary for scale-up the process is determined for one experimental unit and then the unit is copied multiple times. The rest of the work is spent on the industrial and economic problems rather than hydrodynamic and gas-liquid mass transfer issues commonly found in scale-up issues for other bioreactors. 

However, production under static conditions requires more working space and workload, turning the potential industrial scale production more expensive [7]. Therefore, a major goal on BC research has been centered on the optimization of BC production through the design of efficient static culture reactors. Kralisch et al. [42] developed a novel, efficient bioreactor named Horizontal Lift Reactor (HoLiR) (Figure 2.3) that... 

The coupling of encapsulation technologies with cell culture techniques permits the extended use of these bioreactors with complex tissue systems such as islet clusters. Existing reactor systems are also useful in obtaining the basic transport and reaction kinetics parameters necessary to design the novel devices required for biomedical applications. In summary, the relevance of this work to the biotechnology and health care-based industries is in the development, of artificial organ systems, extra-corporeal devices to... 

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