Normal saline dosage

Ophthalmic Dosage Forms. Ophthalmic preparations can be solutions, eg, eye drops, eyewashes, ointments, or aqueous suspensions (30). They must be sterile and any suspended dmg particles must be of a very fine particle size. Solutions must be particle free and isotonic with tears. Thus, the osmotic pressure must equal that of normal saline (0.9% sodium chloride) solution. Hypotonic solutions are adjusted to be isotonic by addition of calculated amounts of tonicity adjusters, eg, sodium chloride, boric acid, or sodium nitrate. 

Dosage 1 mg/kg/dose for 5 doses, the first dose within 24 hours of transplantation, then at intervals of 14 days for four doses. Dilute with 50 ml normal saline over 15 minutes. 

Oprofloxadn, USP. l-Cyclopropyl-6-fIuoro-l.4-dihy-dro-4-oxo-7-(l-pipera/inyl)-3-quinolinecarboxylicacid (Cipro, Cipro IV) is supplied in both oral and parenteral dosage forms. The hydrochloride salt is available in 250-, 500-, and 750-mg tablets for oral administration. Intravenous solutions containing 200 mg and 400 mg are provided in concentrations of 0.2% in normal saline and 1% in 5% dextrose solutions. 

A calcium chloride bolus test dose (10-20 mg/kg up to 1 to 3 g) is the preferred therapy for patients with serious toxicity. In adults, calcium chloride 10% can be diluted in 100 mL normal saline and infused over 5 minutes through a central venous line. If a positive cardiovascular response is achieved with this test dose, a continuous infusion of calcium chloride (20-50 mg/kg per hour) should be started. Calcium gluconate is less desirable to use because it contains less elemental calcium per milligram of final dosage form. Intravenous calcium salts can produce vomiting and tissue necrosis on extravasation." Atropine also may be considered for treatment of bradycardia, but it is seldom sufficient as a sole therapy. ... 

Fosphenytoin. Dosage is based on the phenytoin equivalent 750 mg of fosphenytoin is equivalent to 500 mg of phenytoin. (For example, a loading dose of 1 g phenytoin would require a dose of 1.5 g fosphenytoin.) Dilute twofold to tenfold in 5% dextrose or normal saline and administer no faster than 225 mg/min. 

The most important requirement is that the salt possesses sufficient solubility at physiologically compatible pH values to permit incorporation into the dosage form. Buffering the solution to an appropriate pH can often enhance solubility. Salts may also be prepared in situ in the formulation. This is particularly useful when the main route of administration utilizes the parent drug form. Where the aqueous solubility of the salt is not sufficiently high, co-solvents may need to be added to enhance solubility (e.g. propylene glycol is used as the vehicle in phe-nobarbitone sodium injection). Parenteral solutions based on co-solvent vehicles normally cannot be directly injected intravenously because there is the risk of precipitation at the injection site. Therefore, such products are diluted with isotonic saline or 5%w/v dextrose solution to produce a lower concentration that remains soluble and can be safely administered by infusion. Alternative delivery routes are by subcutaneous or intramuscular administration by which, in... 

Pentostatin (Nipent) is available for IV nse. The recommended dosage is 4 mg/m administered every other week. After hydration with 500 to 1000 mL of 5% dextrose in half-normal (0.45%) saline, the drng is administered by rapid IV injection or by infnsion dnring a period of np to 30 minntes, followed by an additional 500 mL of flnids. Extravasation does not prodnce tissne necrosis. 

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