Nitric oxide cells/macrophages

Stuehr, D. j., and Nathan, C. F. (1989). Nitric oxide. A macrophage product responsible for cytostasis and respiratory inhibition in tumor cells. J. Exp. Med. 169, 1543-1555. 

Yuan, L. Lin, W. Xie, Y Chen, B. Song, J. Development of a ratiometric fluorescent sensor for ratiometric imaging of endogenously produced nitric oxide in macrophage cells. Chem. Commm. 2011, 47, 9372-9374. 

Hong CH, Sun KH, Jin O, Sun SK, Kyung AN, Sang KL. Evaluation of natural products on inhibition of inducible cyclooxygenase (COX-2) and nitric oxide synthase (iNOS) in cultured mouse macrophage cells. J Ethnopharmacol 2002 83 153-159. 

Rafi, MM and Shafaie, Y, 2007. Dietary lutein modulates inducible nitric oxide synthase (iNOS) gene and protein expression in mouse macrophage cells (RAW 264.7). Mol Nutr Food Res 51, 333-340. 

Taylor, M.J., Cross, H.F., Mohammed, A.A., Trees, A.J. and Bianco, A.E. (1996) Susceptibility of Brugia malayi and Onchocerca lienalis microfilariae to nitric oxide and hydrogen peroxide in cell-free culture and from IFN gamma-activated macrophages. Parasitology 112, 315-322. 

Sakata K, Hirose Y, Qiao Z, Tanaka T and Mori H. 2003. Inhibition of inducible isoforms of cyclooxygenase and nitric oxide synthase by flavonoid hesperidin in mouse macrophage cell line. Cancer Lett 199(2)439-145. 

To study the effects of iron overloading on inflammatory cells, Muntane et al. [186] investigated the effect of iron dcxtran administration on the acute and chronic phases of carrageenan-induced glanuloma. It was found that iron dcxtran increased the iron content in plasma and stores, and enhanced lipid peroxidation and superoxide production by inflammatory cells. At the same time, iron dcxtran had a beneficial effect on recovery from the anemia of inflammation. It has been suggested that iron overload may affect nitric oxide production in animals. For example, alveolar macrophages from iron-overloaded rats stimulated with LPS or interferon-7 diminished NO release compared to normal rats [187]. 

IFN-y may also prove valuable in treating a variety of other conditions, and clinical trials for various indications are currently underway. This cytokine shows promise in treating leishmaniasis, a disease common in tropical and subtropical regions. The causative agent is a parasitic protozoan of the genus Leishmania. The disease is characterized by the presence of these protozoa inside certain immune cells, particularly macrophages. IFN-y appears to stimulate the infected macrophage to produce nitric oxide, which is toxic for the parasite. 

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