Neuropsychological development

Wigg NR, Vimpani GV, McMichael AJ, et al. 1988. Port Pirie cohort study Childhood blood lead and neuropsychological development at age two years. J Epidemiol Community Health 42 213-219. [Pg.586]

Chronic exposure to Pb has been shown to cause anaemia, neurotoxic effects, such as reduced cognitive performance and reduced peripheral nerve conduction velocity, and nephrotoxicity. Children are more sensitive to exposure to Pb than adults, especially during the first 2 years of life [41], For children, exposure to lead can cause growth retardation, affect the neuropsychological development and cause encephalopathy [39]. Adverse reproductive effects due to lead exposure have been observed for both men and women. Exposure of pregnant women to low concentrations of lead is associated with miscarriages and low birth weights [40],... [Pg.129]

Rogan WJ et al The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead. N Engl J Med 2001 344 1421. [PMID 11346806]... [Pg.1244]

Examinations of a small number of children (19) believed to have been exposed in utero or in early infancy during the peak of the Michigan PBB-feed contamination episode have not found consistent or marked effects on neuropsychological development. One study found a statistically significant association between performance in neuropsychological development tests and PBB levels in adipose tissues when the children were 2.5-4 years old, but a later examination when the children were 4-6 years old did not find such an association for the same tests. [Pg.36]

Although the available human data regarding developmental effects of PBBs are inconclusive, the results from animal studies strongly suggest that PBBs may cause mild to severe developmental effects in humans, including growth retardation, alteration of neuropsychological development, and structural malformations. [Pg.40]

Polybrominated Biphenyls. Examination of children ( 100 were identified) presumably exposed in utero or in early infancy during the peak of the Michigan PBB contamination episode and whose families lived on farms known to be contaminated with PBBs has not revealed any consistent or maiked abnormalities in the children s physical and neuropsychological development. No significant abnormalities were found by physical and neurological examination of 33 of these exposed children when they had a mean age of... [Pg.165]

Administration of 5 of 18 possible neuropsychological development tests from the McCarthy Scales of Children s Abilities to 19 of these exposed children at 2..S 4 years of age showed a statistically... [Pg.238]

Morreale de Escobar G, Obrcgon MJ, Escobar del Rey F. 2000. Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia J Clin Endocrinol Metab 85(11) 3975-3987. [Pg.443]

Calderdn J, Navarro ME, Jimenez-Capdeville ME, Santos-Diaz MA, Golden A, Rodriguez-Leyva I, Borja-Aburto VH, Diaz-Barriga F (2001) Exposure to arsenic and lead and neuropsychological development in Mexican children. Environ Res, 85 69-76. [Pg.254]

Haddow JE, Palomaki GE, Allan WC, Williams JR, Knight GJ, Gagnon J, O Heir CE, Mitchell ML, Hermos RJ, Waisbren SE, Faix JD, Klein RZ (1999) Maternal thyroid deficiency during pregnancy and subsequent neuropsychological development of the child. N Engl J Med, 341 549-555. [Pg.266]

It has been long known that hypothyroidism leads to retardation and other serious developmental disorders. 52 It has been shown that the neuropsychological development of a fetus is adversely affected when thyroid deficiency occurs in a pregnant woman and her fetus. 53 Even very small reductions in thyroid levels in mothers during pregnancy have been shown... [Pg.364]

Beckett WS, Moore JL, Keogh JP, et al Acute encephalopathy due to occupational exposure to arsenic. British Journal of Industrial Medicine 43 66-67, 1986 Calderon J, Navarro ME, Jimenz-Capdeville ME, et al Exposure to arsenic and neuropsychological development in Mexican children. Environ Res 85 69-76, 2001 DePalma AE Arsine intoxication in a chemical plant. J Occup Med 11 582-587,1969 Eagle H, Magnuson HJ The systemic treatment of 227 cases of arsenic poisoning (encephalitis, dermatitis, blood dyscrasias, jaundice, fever) with 2,3-dimercapto-propanol (BAL). American Journal of Syphilis, Gonorrhea, and Venereal Diseases 30 420-441, 1946... [Pg.119]

Rabinowitz MB, Wang J-D, Soong W-T Children s classroom behavior and lead in Taiwan. Bull Environ Contam Toxicol 48 282-288,1992 Ratcliffe JM Developmental and behavioural functions in young children with elevated blood lead levels. Br J Prev Soc Med 31 258-264, 1977 Rigby EP Low lead levels and mental retardation (letter). Lancet 1 421,1977 Rogan WJ, Dietrich KN, Ware JH, et al The effect of chelation therapy with succimer on neuropsychological development in children exposed to lead. N Engl J Med 344 1421-1426, 2001... [Pg.144]

Is neuropsychological development related to maternal hypothyroidism or to maternal hypothyroxinemia drew attention to the relationship between low maternal free-thyroxine concentrations and impaired neuropsychological development in children (Morreale de Escobar et al., 2004). This hypothesis has since been supported by further clinical and basic data, reinforcing the idea that screening programs should be implemented systematically in order to correct any maternal thyroid underfunction promptly and ultimately prevent fetal brain damage. [Pg.676]

SCREENING FOR CONGENITAL HYPOTHYROIDISM BENEFICIAL EFFECTS ON NEUROPSYCHOLOGICAL DEVELOPMENT... [Pg.203]

In conclusion i) the whole population of Tuscany, including the urban areas, is iodine deficient, ii) several montane areas with moderate iodine deficiency and high prevalence of goiter were found iii) very preliminary data indicate that some impairment of neuropsychological development is present, although this finding needs to be more appropriately controlled. [Pg.371]

On the Evidence for the Hypothesis of Lead Induced Disturbances of Neuropsychological Development... [Pg.92]

These results may tentatively be interpreted to support the hypothesis of a correlation between increased lead-exposure during childhood and disturbances of neuropsychological development. However, they are not unequivocal and pronounced enough to prove a relationship between the lead burden and the observed neuropsychological deficit. For this reason we conducted another study in the city of Stolberg (Winne-... [Pg.94]

From the two neuropsychologic studies carried out in school-age children of the cities of Duisburg and Stolberg, both of which were based on the lead content of deciduous incisor-teeth, we draw the following conclusions as to the effect of lead on the neuropsychological development ... [Pg.96]

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