Neuronal development

GDNF Family - GDNF, NRTN, ARTN, and PSPN RET Alternative splicing results in three isoforms Required for enteric neuron development, kidney development, and spermatogenesis... 

Huang EJ, Reichardt LF (2001) Neurotrophins roles in neuronal development and function. Annu Rev Neurosci 24 677-736... 

Thus the neurotransmitter role of ATP is well established in the periphary and also in sensory systems but its importance in the CNS remains to be elucidated (see Burnstock 1996). That requires the development of more specific antagonists and methods of mapping its location. The strong linkage of its P2x receptors to calcium currents may also provide a role for ATP in more long-term effects such as plasticity and neuronal development and death. 

Lidov, H.G.W., and Molliver, M.E. An immunohistochemical study of serotonin neuron development in the rat Ascending pathways and terminals fields. Brain Res Bull 8 389-430, 1982. 

Raff The ventralizing signals such as Sonic hedgehog that are required for motor neuron development are also required for oligodendrocyte precursors to develop from CNS stem cells, at least in the spinal cord. 

Guilarte TR, Miceli RC, Jett DA. 1995. Biochemical evidence of an interaction of lead at the zinc allosteric sites of the NMDA receptor complex effects of neuronal development. Neurotoxicology 16 63-71. 

Regan CM. 1993. Neural cell adhesion molecules, neuronal development and lead toxicity. Neurotoxicology 14 69-74. 

Jose, M., Nair, D. K., Reissner, C., Hartig, R. and Zuschratter, W. (2007). Photophysics of clomeleon by FLIM Discriminating excited state reactions along neuronal development. Biophys. J. 92, 2237-54. 

The lipid compositions of plasma membranes, endoplasmic reticulum and Golgi membranes are distinct 26 Cholesterol transport and regulation in the central nervous system is distinct from that of peripheral tissues 26 In adult brain most cholesterol synthesis occurs in astrocytes 26 The astrocytic cholesterol supply to neurons is important for neuronal development and remodeling 27 The structure and roles of membrane microdomains (rafts) in cell membranes are under intensive study but many aspects are still unresolved 28... 

Tyrosine phosphorylation is involved in every stage of neuronal development 426... 

Benowitz, L. I. and Routtenberg, A. GAP-43 an intrinsic determinant of neuronal development and plasticity. Trends Neurosci. 20 84-91,1997. 

Henderson CE. 1996. Role of neurotrophic factors in neuronal development. Curr Opin Neurobiol 6 64-70. 

IBDNF Neive growth factor Neuronal development Cell survival Mood enhancer... 

Kanungo J, Zheng YL, Amin ND, Kaur S, Ramchandran R, Pant HC (2009) Specific inhibition of cyclin-dependent kinase 5 activity induces motor neuron development in vivo. Biochem Biophys Res Commun 386 263-267... 

Folate deficiency during pregnancy is a major contributor to neural tube defects because of the critical role of folate in neuronal development. 

Neurotrophic factors play a central role in development and maintenance of neuronal cells. After release from the target cells, they bind specific receptors on the nerve termini, are internalized and carried up the axon to the perikaryon by retrograde transport. This process helps guide the direction of neurite growth (i.e. a chemoattractant activity) during neuronal development, and also serves to nourish the developing cell. Once established, the process of retrograde transport must continue if the cell is to survive and remain differentiated. 

FUTURE PROSPECTS ALTERATION OF NEURONAL DEVELOPMENT AND VULNERABILITY TO PSYCHOPATHOLOGY... 

Ciarenello, R.D., Vanderberg, S.R., and Anders TF. (1982) Intrinsic and extrinsic determinants of neuronal development relevance to infantile autism./Autism Dev Disorders 12 115-145. 

Represa A, Ben-Ari Y (2005) Trophic actions of GABA on neuronal development. Trends Neurosci 28 278-283... 

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