Membrane microdomains

Fyn is a nonreceptor tyrosine kinase related to Src that is frequently found in cell junctions. Die protein is N-myristoylated and palmitoylated and thereby becomes associated with caveolae-like membrane microdomains. Fyn can interact with a variety of other signaling molecules and control a diversity of biological processes such as T cell receptor signaling, regulation of brain function, and adhesion mediated signaling. 

Viola A, Schroeder S, Sakakibara Y, Lanzavecchia A. T lymphocyte costimulation mediated by reorganization of membrane microdomains. Science 1999 283(5402) 680-682. 

Popik W, Alee TM. CD4 receptor localized to non-raft membrane microdomains supports HIV-1 entry. Identification of a novel raft localization marker in CD4. J Biol Chem 2004 279(1) 704-712. 

Zacharias, D. A., Violin, J. D., Newton, A. C. and Tsien, R. Y. (2002). Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 296, 913-6. 

Vermeer, J. E., Van Munster, E. B., Vischer, N. O. and Gadella, T. W., Jr. (2004). Probing plasma membrane microdomains in cowpea protoplasts using lipidated GFP-fusion proteins and multimode FRET microscopy. J. Microsc. 214, 190-200. 

Bhat, R. A., Miklis, M., Schmelzer, E., Schulze-Lefert, P. and Panstruga, R. (2005). Recruitment and interaction dynamics of plant penetration resistance components in a plasma membrane microdomain. Proc. Natl. Acad. Sci. USA 102, 3135 40. 

K. E. Pace, C. Lee, P. L. Stewart, and L. G. Baum, Restricted receptor segregation into membrane microdomains occurs on human T cells during apoptosis induced by galectin-1, J. Immunol., 163 (1999) 3801-3811. 

The lipid compositions of plasma membranes, endoplasmic reticulum and Golgi membranes are distinct 26 Cholesterol transport and regulation in the central nervous system is distinct from that of peripheral tissues 26 In adult brain most cholesterol synthesis occurs in astrocytes 26 The astrocytic cholesterol supply to neurons is important for neuronal development and remodeling 27 The structure and roles of membrane microdomains (rafts) in cell membranes are under intensive study but many aspects are still unresolved 28... 

Y. Lavie, G. Fiucci, M. Czarny, and M. Liscovitch. Changes in membrane microdomains and caveolae constituents in multidrug-resistance cancer cells. 

Thomsen P, Roepstorff K, Stahlhut M, van Deurs B. Caveolae are highly immobile plasma membrane microdomains, which are not involved in constitutive endocytic trafficking. Mol Biol Cell 2002 13(l) 238-250. 

Wahrle, S., Das, P., Nyborg, A.C., et al. (2002) Cholesterol-dependent gamma-secretase activity in buoyant cholesterol-rich membrane microdomains. Neurobiol. Dis., 9, 11-23. 

Zajchowski, L.D. Robbins, S.M. (2002) Lipid rafts and little caves compartmentalized signalling in membrane microdomains. Eur. J. Biochem. 269, 737-752. 

Cordeaux Y, Briddon SJ, Alexander SP, Kellam B, Hill SJ (2008) Agonist-occupied A3 adenosine receptors exist within heterogeneous complexes in membrane microdomains of individual living cells. FASEB J 22(3) 850-860... 

Martens JR, O Connell K, Tamkun M. Targeting of ion channels to membrane microdomains localization of KV channels to lipid rafts. Trends Pharmacol Sci. 2004 25 16-21. 

Maxfield FR. Plasma membrane microdomains. Curr Opin Cell Biol. 2002 14 483-487. 

Zhang, W., Trible, R. P., and Samelson, L. E. 1998. LAT palmitoylation Its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity 9 239-246. 

Is TLR4 Recruited in Membrane Microdomains Upon Ligand Engagement ... 

Bruckner, K. et al. (1999). EphrinB ligands recruit GRIP family PDZ adaptor proteins into raft membrane microdomains. Neuron 22, 511-524. 

Laude, A.J., and Prior, I.A., 2004, Plasma membrane microdomains Organization, function and trafficking. Mol. Membr. Biol. 21 193-205. 

SNCA is located on chromosome 4q22.1, has six exons, and encodes a 140 amino acid protein. The N-terminus consists of an amphipathic a-helical domain that associates with membrane microdomains, known as lipid rafts (Fortin et al., 2004). The central region contains a fibrillization region, and the C-terminus contains an aggregation inhibition region (Fig. 6) (Bisaglia et al., 2008). 

All aminopeptidases identified so far contain a glycosylphosphatidyl inositol (GPI) moiety through which they anchor to membranes [123,124,143,144]. These GPI-anchored proteins may play an essential role in targeting Cry toxins to lipid raft membrane microdomains and leading to toxin aggregation and pore fimnation [145]. Removal of the GPI-anchor with bacterial or endogenous phospholipase C converts flie membrane-... 

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