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Sonic hedgehog

Raff The ventralizing signals such as Sonic hedgehog that are required for motor neuron development are also required for oligodendrocyte precursors to develop from CNS stem cells, at least in the spinal cord. [Pg.110]

The best examples of pleiotropy have been provided by developmental biologists. Two examples illustrate the pleiotropic action of developmental genes. Sonic hedgehog participates in the formation of the different cell types that form the neural tube, in limb development and in somitogenesis, a process by which mesodermic cells aggregate to form bones and muscles. [Pg.182]

Wechsler, R. J. and Scott, M. P. (1999), Control of neuronal precursor proliferation in the cerebellum by sonic hedgehog , Neuron, 22, 103-114. [Pg.187]

Figure 14.19 Simplified schematic overview of the directed differentiation of human embryonic stem cells to form differentiated dopamine like neurons. The full pathway details are available in Yan, Y., Yang, D., Zarnowska, E.D., Du, Z., Werbel, B., Valliere, C., etai 2005. Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells. Stem Cells 23, 781-790. FGF fibroblast growth factor SHH sonic hedgehog (a regulatory protein)... Figure 14.19 Simplified schematic overview of the directed differentiation of human embryonic stem cells to form differentiated dopamine like neurons. The full pathway details are available in Yan, Y., Yang, D., Zarnowska, E.D., Du, Z., Werbel, B., Valliere, C., etai 2005. Directed differentiation of dopaminergic neuronal subtypes from human embryonic stem cells. Stem Cells 23, 781-790. FGF fibroblast growth factor SHH sonic hedgehog (a regulatory protein)...
The development of motor neurons and oligodendrocytes is dependent on sonic hedgehog 508... [Pg.503]

The development of motor neurons and oligodendrocytes is dependent on sonic hedgehog. One of the most intensely studied cell types in the CNS is the spinal cord... [Pg.508]

Zhu, G., Mehler, M. F., Zhao, J., Yu Yung, S. and Kessler, J. A. Sonic hedgehog and BMP2 exert opposing actions on proliferation and differentiation of embryonic neural progenitor cells. Dev. Biol. 215 118-129,1999. [Pg.515]

Calcutt, N. A., Allendoerfer, K. L., Mizisin, A. P. et al. Therapeutic efficacy of sonic hedgehog protein in experimental diabetic neuropathy. /. Clin. Invest. Ill 507-514,2003. [Pg.627]

Expression of another set of genes establishes the right-left axis and characteristic asymmetries of the body.333-336 In the chick activin 2(3, also a member of the TGF-P family, as well as Nodal and Sonic hedgehog (Shh) participate in control. The gene Pitx2 is a downstream transcription target for this signaling cascade in vertebrates. [Pg.1899]

Chiang, C., Litingtung, Y., Lee, E., Young, K.E., Corden, J.L., Westphal, H Beachy, P.A. (1996). Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature (London), 383,407-413. [Pg.117]

Marigo, V., Johnson, R.L., Vortkamp, A., Tabin, C. (1996). Sonic hedgehog differentially regulates expression of GLI and GL13 during limb development. Dev. Biol. 180(1), 273-283. [Pg.118]


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