Neuronal cell death

Neuronal cell deterioration Neuronal cell death... 

Martin LJ (2001) Neuronal cell death in nervous system development, disease, and injury (Review). Int J Mol Med 7 455—478... 

Kaul M, Ma Q, Medders KE, Desai MK, Lipton SA (2007) HIV-1 coieceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death Differ 14 296-305... 

Jung H, Toth PT, White PA, Miller RJ (2008) Monocyte chemoattractant protein-1 functions as a neuromodulator in dorsal root ganglia neurons. J Neurochem 104 254-263 Kahn L, Alonso G, Normand E, Manzoni OJ (2005) Repeated morphine treatment alters polysia-lylated neural cell adhesion molecule, glutamate decarboxylase-67 expression and ceU proliferation in the adult rat hippocampus. Em J Nemosci 21 493-500 Kaul M, Ma Q, Medders KE, Desai MK, Lipton SA (2007) HIV-1 coreceptors CCR5 and CXCR4 both mediate neuronal cell death but CCR5 paradoxically can also contribute to protection. Cell Death Differ (2) 296-305... 

Henninger N, Bouley J, Nelligan JM, Sicard KM, Fisher M. Normobaric hyperoxia delays perfusion/diffusion mismatch evolution, reduces infarct volume, and differentially affects neuronal cell death pathways after suture middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 2007 Epub Feb 21. 

Rossi AD, Viviani B, Zhivotovsky B, Manzo L, Orrenius S, Vahter M, Nicotera P. 1997. Inorganic mercury modifies Ca + signal, triggers apoptosis and potentiates NMDA toxicity in cerebellar granule neurons. Cell Death Differentiation 4 317-324. 

Boje, K.M. and Arora, P.K. (1992). Microglial-produced nitric oxide and reactive nitrogen oxides mediate neuronal cell death. Brain Res. 587, 250-256. 

Yonekawa, Y., Harada, A., Okada, Y. et al. Defect in synaptic vesicle precursor transport and neuronal cell death in KIF1A motor protein-deficient mice. /. Cell Biol. 141 431—441, 1998. 

Pucha, G. V. and Iohnson,E. M. Men are but worms neuronal cell death in C. elegans and vertebrates. Cell Death Differ. 11 38-48, 2004. 

IGF I has recently been the focus of considerable interest due to its actions on motor neurons. It can prevent normal motor neuron cell death during development, reduce the loss of these cells following nerve injury and enhance axonal regeneration. In the adult, injection of IGF I results in sprouting of motor neuron terminals and increases the size of the neuromuscular junction. These and other studies suggest potential therapeutic applications of IGF I in several neurological diseases including amyotrophic lateral sclerosis and peripheral neuropathies. 

In cerebrovascular diseases, the phospholipase-A2-related signaling triggered by ischemia-reperfusion may be part of a delicate balance between neuroprotection and neuronal cell death 584... 

Both PAF [57] and COX-2 are potent mediators of the injury/inflammatory response (Fig. 33-5). PAF and COX-2 are also interrelated in neuronal plasticity. The PAF transcriptional activation of COX-2 may provide clues about novel neuronal cell-death pathways. In fact, the delayed induction of COX-2 by kainic acid precedes selective neuronal apoptosis by this agonist in the hippocampus [42,58]. 

The brain has an absolute dependence on the blood for its immediate supply of oxygen and energy substrates. Interruption of oxygen or substrate supply by compromise of pulmonary or cardiovascular function or metabolic factors results in encephalopathy and, if prolonged, neuronal cell death. The brain uses approximately 20% of the total oxygen supply of the body. While glucose remains the primary energy substrate for the brain, alternative substrates maybe used under certain circumstances (see Ch. 31). 

Oxidative stress contributes to selective neuronal cell death in thiamine-deficiency 600... 

The suggestion that eNOS-derived NO is implicated in neuronal cell death mechanisms in thiamine deficiency contrasts with current views in cerebral ischemia in which increased eNOS-derived NO is thought to play a neuro-protective role by virtue of its vasodilatory potential. 

Yuan, Y., Lipinski, M., and Degterev, A. Diversity in the mechanisms of neuronal cell death. Neuron 40 401-413, 2003. 

Prudlo, J., Koenig, J., Graser, J. et al. Motor neuron cell death in a mouse model of FALS is not mediated by the p53 cell survival regulator. Brain Res. 879 183-187,2000. 

The precise structure of the infectious agent and the cause of neuronal cell death in prion disease remain unclear. The current working hypothesis is that an abnormal... 

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