Neuron selection

Findings obtained from experimental studies suggest that induction of iNOS mediates inflammatory or ischemic brain damage and that excessively activated nNOS under excitotoxic or ischemic conditions produces NO that is toxic to surrounding neurons. Selective inhibition of iNOS or nNOS may be neuroprotec-tive. This is also the case in glaucoma and diabetic... 

Yang, Y., et al.. Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila. Neuron, 2003, 37(6), 911-24. 

Population Thinking and Neuronal Selection Metaphors or Concepts ... 

Andrew, D. and Craig, A.D. Spinothalamic lamina 1 neurons selectively sensitive to histamine a central neural pathway for itch. Nat. Neurosci. 4, 72-77 (2001). 

Eight radioiodinated derivatives of benzovesamicol, 257-264, have been synthesized and their in vivo neuronal selectivity tested. 

Rafols, J. A., Daya, A. M., O Neil, B. J., Krause, G. S., Neumar, R. W., and White, B. C., Global brain ischemia and reperfusion Golgi apparatus ultrastructure in neurons selectively vulnerable to death, Acta Neuropathol., 90, 17, 1995. 

Murphy KPSJ, Greenfield SA. Neuronal selectivity of ATP-sensitive potassium channels in guinea pig substantia nigra by response to anoxia. J Physiol (Lond) 1992 453 167-183. 

As low levels of MAO-A were detected in serotonergic neurons, selective MAO-A inhibitors were shown to increase brain 5-HT and to exert an antidepressant effect. MAO-B is also present in serotonergic neurons and, by degrading other amines, it may contribute to the purity of 5-HT delivered to the synaptic cleft. Both MAO-A and -B are found in noradrenergic neurons. Within synaptosomes of these neurons, MAO-A plays an important role in the deamination of noradrenaline and dopamine in the hypothalamus and striatum, respectively. On the other hand, MAO-B exerts a major role in the extraneuronal dopamine metabolism when dopamine uptake is impaired [2]. 

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