Nerve agents development

This series of agents are a new class of nerve agents developed by the former Soviet Union. Very little information is available about them.. It has been reported that this class of agents are five to eight, possibly as much as lOx stronger as VX. They are conjectured to be the unitary nerve agents from the binary novichoks. A-230 maybe the result of novichok- and novichok- combining. 

G-series nerve agents - a series of nerve agents developed by the Germans, that includes Tabun (GA), Sarin (GB), Soman (GD), Ethyl Sarin (GE). 

V-agents - persistent, highly toxic nerve agents developed in the mid-1950s and absorbed primarily through the skin. 

Furlong, C.D., W.F. Li, L.G. Costa, R.J. Richter, D.M. Shih, and A.J. Lusis. 1998. Genetically determined susceptibility to organophosphorus insecticides and nerve agents Developing a mouse model for die human PONl polymorphism. Neurotoxicology 19 645-650. 

Common nerve agents developed for chemical warfare purposes include the G-series (so named because... 

The recent development and comparative application of modern separation techniques with regard to determination of alkylphosphonic acids and lewisite derivatives have been demonstrated. This report highlights advantages and shortcomings of GC equipped with mass spectrometry detector and HPLC as well as CE with UV-Vis detector. The comparison was made from the sampling point of view and separation/detection ability. The derivatization procedure for GC of main degradation products of nerve agents to determine in water samples was applied. Direct determination of lewisite derivatives by HPLC-UV was shown. Also optimization of indirect determination of alkylphosphonic acids in CE-UV was developed. Finally, the new instrumental development and future trends will be discussed. 

Brown, D.F., A.J. Policastro, W.E. Dunn, R. A. Carhart, M. A. Lazaro, W. A. Freeman, and M. Krumpolc. Development of the Table of Initial Isolation and Protective Action Distances for the 2000 Emergency Response Guidebook, Argonne National Laboratory Report No. ANL/DIS-00-1. October 2000. Buckles, L.C. and S.M. Lewis. "S-(2-Diisopropylamino-ethyl)0-ethyl methylphosphonothioate Stabilized with Soluble Carbodiimides," United States Patent 4012464, September 24,1965. Centers for Disease Control and Prevention. "Case Definition Nerve Agents or Organophosphates." March 15,2005. 

Edgewood Research Development, and Engineering Center, Department of the Army. Material Safety Data Sheet (MSDS) for Lethal Nerve Agent (GA). Aberdeen Proving Ground, MD Chemical Biological Defense Command, Revised February 28,1996. 

Nitrogen mustard agents were introduced before the development of nerve agents. Nitrogen mustard agent HN-1 was developed by accident by the German and Czech pharmaceutical industries. It was originally developed to remove warts and kill... 

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