Nausea nervous excitability

Adverse effects can include dizziness, headache, nervousness, excitement, nausea, tachycardia and drowsiness. 

Overdose of coffee may result in restlessness, nervousness, excitement, insomnia, flushed face, frequent urination, stomach ache, nausea, tremors, talkativeness, periods of inexhaustibility, and irritability (Hughes et al. 1991). 

Properties Wh. cryst. powd. odorless bitter taste sol. in DMSO, abs. ethanol, methanol, methylene chloride, chloroform sol. 10-50 mg/ml in water, acetone m.w. 390.87 m.p. 130-135 C Toxicology LD50 (oral, rat) 306 mg/kg, (subcut., rat) 365 mg/kg, (IV, mouse) 26,100 pg/kg, (IP, mouse) 76,700 pg/kg highly toxic by ing., IP, subcut., IV routes causes CNS effects in humans exposure to Ig. amts, may cause hallucinations, convulsions, death may cause drowsiness, dizziness, sleeplessness, nervousness, excitability, sensitivity reactions, dry mouth, weakness, anorexia, nausea, vomiting, headache, hypotension, polyuria, heartburn, diplopia, dysuria, blurred vision, dermatitis... 

Ethanol is classified for medical purposes as a central nervous system (CNS) depressant. Its effects—that is, being drunk—resemble the human response to anesthetics. There is an initial excitability and increase in sociable behavior, but this results from depression of inhibition rather than from stimulation. At a blood alcohol concentration of 0.1% to 0.3%, motor coordination is affected, accompanied by loss of balance, slurred speech, and amnesia. When blood alcohol concentration rises to 0.3% to 0.4%, nausea and loss of consciousness occur. Above 0.6%, spontaneous respiration and cardiovascular regulation are affected, ultimately leading to death. The LD50 of ethanol is 10.6 g/kg (Chapter 1 Focus On). 

Side effects may be as mild and rare as headache, nausea, and stomach upset for saw palmetto [23,24], However, some supplements may have serious side effects. Hypertension, euphoria, restlessness, nervousness, insomnia, skin eruptions, edema, and diarrhea were reported in 22 patients following long-term ginseng use at an average dose of 3 g of ginseng root daily [38]. Side effects reported with valerian use include headaches, hangover, excitability, insomnia, uneasiness, and cardiac disturbances. Valerian toxicity including ataxia, decreased sensibility, hypothermia, hallucinations, and increased muscle relaxation have been reported [39]. 

By ingestion, the mean lethal dose for humans probably lies between 120 and 180ml. Symptoms include burning pain in the mouth and throat, abdominal pain, nausea, vomiting, and occasionally diarrhea. Central nervous system effects are excitement, ataxia, confusion, and stupor. Convulsions may occur several hours after ingestion. Fever and tachycardia are common, and death is usually attributed to respiratory failure. ... 

Adverse reactions include the following Hypotension palpitations tachycardia drowsiness restlessness excitation nervousness insomnia euphoria blurred vision diplopia vertigo tinnitus auditory and visual hallucinations (particularly when dosage recommendations are exceeded) urticaria rash dry mouth anorexia nausea vomiting diarrhea constipation cholestatic jaundice (cyclizine) urinary frequency difficult urination urinary retention dry nose and throat. 

Common side effects include nausea, vomiting, heartburn, diarrhoea. Central effects include drowsiness, weakness, nervousness, insomnia, confusion, excitement and hallucinations. 

Cardiac glycosides affect all excitable tissues, including smooth muscle and the central nervous system. The gastrointestinal tract is the most common site of digitalis toxicity outside the heart. The effects include anorexia, nausea, vomiting, and diarrhea. This toxicity is caused in part by direct effects on the gastrointestinal tract and in part by central nervous system actions. 

SAFETY PROFILE Poison by ingestion, subcutaneous, intramuscular, intraperitoneal, and intravenous routes. Experimental reproductive effects. Human systemic effects by intramuscular and intravenous routes wakefulness, euphoria, hallucinations or distorted perceptions, tremors, convulsions, excitement, motor activity changes, muscle weakness, analgesia, withdrawal, parasympathomimetic effects, nausea or vomiting, and dermititis. Can cause drug dependency and other central nervous system effects. An analgesic. When heated to decomposition it emits toxic fumes of NOx. See also ALLYL COMPOUNDS. 

SAFETY PROFILE Experimental poison by subcutaneous route. Moderately toxic to humans by ingestion. Moderately toxic experimentally by ingestion, intraperitoneal, and intravenous routes. An experimental teratogen. Human systemic effects by multiple and unspecified routes toxic psychosis, excitement, respiratory stimulation, nausea or vomiting, and sweating. Experimental reproductive effects. Mutation data reported. A powerful irritant which affects the central nervous system. Incompatible with ferric salts, mineral acids, iodine, lead acetate, silver nitrate, sodium phosphate powder. When heated to decomposition it emits toxic fumes of Na20. 

Folic acid administered to healthy adults in a daily dose of 15 mg for I month resulted in gastrointestinal di.sturbances (including anorexia, nausea and pain) and central nervous system effects (including sleep disturbances, vivid dreams, malaise, irritability and increased excitability). ... 

In normal transmission of a nervous impulse from nerve to nerve, acetylcholine is released into the synapse in order to excite the receiving neuron (Figure 5.10). Unless acetylcholine is rapidly broken down, the receiving nerve is constantly fired, resulting in uncoordinated muscle movement, nausea, dizziness, and eventually seizures and unconsciousness. The serine enzyme acetylcholinesterase is responsible for the expedient breakdown of the neurotransmitter acetylcholinesterase. 

Yohimbine is well tolerated at the oral doses used for erectile dysfunction. The main side effects are nausea, dizziness, and nervousness. Headache and skin flushing have also been reported. Yohimbine has no significant effect on jS-adrenergic receptors, and its effect on blood pressure has not been adequately evaluated. Common side effects after parenteral administration include sweating, nausea, and vomiting. Yohimbine penetrates the blood-brain barrier and can produce a complex pattern of responses (93). The central effects include anti-diuresis, a general picture of central excitation including elevated blood pressure and heart rate, increased motor activity, irritability, and tremor. 

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