National Human Adipose Tissue Survey

The most recent National Human Adipose Tissue Survey did not detect endrin in adipose tissues from the general U.S. population (Stanley 1986). Endrin also was not detected in adipose breast tissue from breast cancer patients (n=5) or controls (n=5) in the United States (Djordjevic et al. 1994). A 1984 study based on autopsied adipose tissue from 141 cadavers from six Canadian Great Lakes municipalities showed no detectable concentrations of endrin (detection limit 2.4 ppb) (Williams et al. 1988). In a 1990-91 survey, only very low levels of endrin (average concentration 3.27 ng/g (ppb) range 0.23-8.56 ng/g [ppb] lipid)... 

Stanley JS. 1986. Broad scan analysis of the FY82 national human adipose tissue survey specimens Volume I - executive summary. Washington, DC U.S. Environmental Protection Agency, Office of Toxic Substances. EPA/560/5-86/037. 

Phillips LJ, Birchard GF. 1991a. Regional variations in human toxics exposure in the USA An analysis based on the national human adipose tissue survey. Arch Environ Contam Toxicol 21 (2) 159-168. 

In an early report of the 1982 annual results of the National Human Adipose Tissue Survey (NHATS), a compound identified as di- -octylphthalate was reportedly detected in 31% of the composite human adipose tissue samples taken in the various regions of the United States that year. Concentrations in lipid ranged from below the level of detection (9 ng/sample) to a maximum of 850 ng/g (EPA 1986d). However, a later report of the 1982 results stated that the chemical detected was not di- -octylphthalate, but was actually diethylhexyl phthalate (EPA 1989b). 

Mack, G., et. al.. Survey Design for the National Human Adipose Tissue Survey, Battelle Columbus Laboratories, Columbus,... 

The general purpose of the National Human Adipose Tissue Survey is the detection and quantification of the prevalences of selected toxic substances in the general U.S. population. The specific objectives of the survey are ... 

Table I. Compounds Monitored in the National Human Adipose Tissue Survey...

The Program Strategy for the National Human Adipose Tissue Survey", U.S. Environmental Protection Agency, draft document, 1984. 

NHATS National Human Adipose Tissue Survey NHANES National Health and Nutrition Examination Survey NHEXAS National Human Exposure Assessment Survey NIEHS, National Institute of Environmental Health Sciences... 

NHATS National Human Adipose Tissue Survey. 

EPA. 1986a. Broad scan analysis of the FY82 national human adipose tissue survey specimens. Vol. 

PAHs have generally not been detected in surveys of human tissue, presumably because the compounds are fairly rapidly metabolized. Phenanthrene was the only PAH detected in the 1982 National Human Adipose Tissue Survey it was found in trace concentrations in 13% of the samples (EPA 1986). Acenaphthylene, acenaphthene, fluorene, and chrysene were not found at levels below the detection limit (0.010 pg/g 10 ppt). However, autopsies performed on cancer-free corpses found PAH levels of 11-2,700 ppt (ng/g) in fat samples (Obana et al. 1981). Several PAHs were detected, including anthracene, pyrene, benzo[e]pyrene, benzo[k]fluoranthene, benzo[a]pyrene, and benzo[g,h,i]perylene, with pyrene being detected in the highest concentrations. A similar study done on livers from autopsied cancer-free corpses found levels of 6-500 ppt (ng/g) of all of the same PAHs except benzo[e]pyrene, which was not detected (Obana et al. 1981). As in the fat sample studies, pyrene appeared in the highest concentrations in the liver, but the overall levels were less than in fat. 

The National Human Adipose Tissue Survey (NHATS), conducted in 1982 using packed column gas chromatography (GC), found that the concentrations of total PCBs in composite human adipose tissue ranged from 14 to 1,700 ng/g (0.014-1.7 ppm) Gipid basis) (EPA 1986b). The maximum concentration was found in a sample composite collected from the South Atlantic region (Virginia, North Carolina,... 

National Human Adipose Tissue Survey National Occupational Exposure Study National Priorities List National Toxicology Program Native American NBAS... 

The National Human Adipose Tissue Survey for 1986 identified styrene residues in 100% of all samples of human fat tissue taken in 1982 in the United States. 

---