Nanofiber mesh

Furthermore, meshes have been composed of multilayers consisting of different polymers. Matsuda and coworkers produced bilayer meshes of a thick polyurethane microfiber mesh and a thin nanofiber mesh composed of type I collagen. The material decouples mechanical properties from the biochemical functionality of collagen to form a prototype scaffold for artificial grafts [194],... 

Synthetic nanofiber matrices can provide physically and chemically stable 3D surfaces for ex vivo growth of cells. Meiners and coworkers showed that fibroblasts or rat kidney cells that have been grown on electrospun polyamide nanofiber meshes displayed all the characteristics of their counterparts in vivo [205], In addition, breast epithelial cells underwent morphogenesis to form multicellular spheroids containing lumens. 

Guimaraes A et al (2010) Solving cell infiltration limitations of electrospun nanofiber meshes for tissue engineering applications. Nanomedicine 5(4) 539-554... 

He W et al (2006) Biodegradable polymer nanofiber mesh to maintain functions of endothelial cells. Tissue Eng 12(9) 2457-2466... 

He, W., Ma, Z.W., Yong, T., Teo, W.E., Ramakrishna, S., 2005. Fabrication of collagen-coated biodegradable polymer nanofiber mesh and its potential for endotheUal cell growth. Biomaterials 26, 7606—7615. 

Nanofibers have applications in medicine, artificial organ components, tissue engineering, implant material, drug deliveiy, wound dressing, and medical textile materials. Nanofiber meshes... 

Araujo et al. (2008) prepared PCL electrospun nanofiber meshes coated with a biomimetic calcium phosphate (BCP) layer that mimics the extracellular microenvironment found in the human bone structure. The deposition of a calcium phosphate layer, similar to the inorganic phase of bone, on the PCL nanofiber meshes was... 

Araujo, J.V., Martins, A., Leonor, I.B., Pinho, E.D., Reis, R.L. and Neves, N.M. 2008. Surface controlled biomimetic coating of polycaprolactone nanofiber meshes to be used as bone extracellular matrix analogues. 

In vitro osteogenic differentiation of human mesenchymal stem cells and in vivo bone formation in composite nanofiber meshes. Tissue Eng. Part A,... 

On the other hand, the authors have innovated a nanofiber mesh for the removal of toxins from the blood, which they are hopeful may be incorporated into wearable blood purification systems for kidney failure patients (Fig. 5.4.8) [29]. We made their nanoliber mesh using two components a blood-compatible primary matrix polymer made from polyethylene-co-vinyl alchohol, and several different forms of zeolites. Zeolites have... 

FIGURE 5.4.8 (a) Schematic of a novel concept of a wearable blood purification system with nanofiber mesh, (b) SEM image of a nanofiber mesh containing zeolite, (c) Creatinine adsorption increased depending on the zeolite content in the nanofiber meshes. 

Yang, Y., Wimpenny, I., Aheame, M., 2011. Portable nanofiber meshes dictate cell orientation throughout three-dimensional hydrogels. Nanomedicine Nanotechnology, Biology, and Medicine 7 (2), 131—136. 

Silk proteins EGF Nanofiber mesh Optimal wound closure High healing rate ReepitheUalization Collagen synthesis Mouse Gil et al. (2013)... 

Choi, J.S., Lee, S.J., Christ, G.J., Atala, A., Yoo, JJ., 2008. The influence of electrospun aligned poly(epsilon-caprolactone)/coUagen nanofiber meshes on the formation of self-aligned skeletal muscle myotubes. Biomaterials 29, 2899—2906. 

Nanofibers and webs are capable of delivering medicines directly to internal tissues. Anti-adhesion materials made of cellulose are already available from companies such as Johnson Johnson and Genzyme Corporation [19]. Namekawa etal. [20] developed a zeolite-polymer composite nanofiber mesh to remove uremic toxins for blood purification. The nanofiber is composed of blood compatible poly(ethylene-co-vinyl alcohol) (EVOH) as the primary matrix polymer and zeolites which are capable of selectively adsorbing uremic toxins such as creatinine. It was suggested that the proposed composite fibers have the potential to be utilized as a new approach to removing nitrogenous waste products from the bloodstream without the requirement of specialized equipment [21]. Kidney failure patients can have an alternative to dialysis in the form of nanofiber mesh which is portable and wearable. 

Kim, T. G. Park, T. G. Biomimicking extracellular matrix cell adhesive RGD peptide modified electrospun Poly(D,L-lactic-co-glycolic acid) nanofiber mesh. Tissue Ene. 2006.12,221-33. 

Electrospinning is a technique used for the production of polymer nanofiber meshes. The use of biodegradable and biocompatible pol miers to produce nanofibers that closely mimic the extracellular matrix of different tissues has opened a wide range of possibilities for the application of electrospinning in tissue engineering (8). Functional materials formed by the electrospinning technology are of interest for many bioactive applications. The issues of this topic have been reviewed (9). 

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