Neuropsychiatric effects

Su, T.-P., Pagliaro, M., Schmidt, P. J., Pickar, D., Wolkowitz, O., and Rubinow, D. R. 1993. Neuropsychiatric effects of anabolic steroids in male normal volunteers. Journal of the American Medical Association 269 2760-2764. 

Hematological toxicity 10 Neuropsychiatric effects/ abuse liability/dependency 12... 

Uses Prevention Rx influenza A (including 2009 Novel HlNl ) B, Action -1- Viral neuraminida.se Dose AduUs. Tx 75 mg PO bid X 5 d Prophylaxis 75 mg PO daily X 10 d Peds >1 yr. (Authorized 2009 by FDA for emergency use in <1 y) PO bid dosing <15 kg 30 mg 15-23 kg 45 mg 24-40 kg 60 mg >40 kg Adult dose -1- w/ renal impair Caution [C, /—] Contra Component allergy Disp Caps SE NA, insomnia, rqjorts of neuropsychiatric events in children (self-injury, confusion, delirium) caution urged in children as SEs are often more severe that the HlNl influenza Interaction T Effects W/ probenecid EMS Beware acute neuropsychiatric effects esp in children OD May cause NA symptomatic and supportive... 

Eor preventive treatments, the adverse effects of the beta blockers are classical for this class bradycardia, bronchospasm, hypotension, nightmares and depression. Indoramine induces neuropsychiatric effects (sedation, asthenia) and cardiovascular disorders (hypotension). Eluanarizine is strictly contraindicated in patients with Parkinsonism and depression. 

Nnadi CU, Mimiko OA, McCurtis HL Cadet JL (2005). Neuropsychiatric effects of... 

Anand A, Charney DS, Oren DA. Attenuation of the neuropsychiatric effects of ketamine with lamotrigine. Support for hyperglutamatergic effects of N -methyl-D-aspartate receptor antagonists. Arch Gen Psychiatry 2000 57 270-276. 

Neuropsychiatric effects of glucocorticoids, like hallucinations, can result from intra-articular administration (SEDA-22, 444) (463). 

Miller BL, Mena I, Giombetti R, Villanueva-Meyer J, Djenderedjian AH. Neuropsychiatric effects of cocaine SPECT measurements. J Addict Dis 1992 ll(4) 47-58. 

The pharmacological effects of the R- and 5-enantiomers of ketamine have been compared in 11 subjects who received //-ketamine 0.5 mg and then 5-ketamine 0.15 mg, separated by 1 week (432). Before and after each drug administration they were subjected to a painful stimulus using a nerve stimulator applied to the right central incisor tooth. Pain suppression was equal with the two drugs. The subjects reported more unpleasant psychotomimetic effects with 5-ketamine and more pleasant effects with //-ketamine. Seven of eleven subjects preferred //-ketamine, while none preferred 5-ketamine. These results suggest that the neuropsychiatric effect of ketamine may be predominantly due to the 5-enantiomer, and that //-ketamine may be a better alternative. This study is in direct distinction to earlier work suggesting that //-ketamine is responsible for most of the undesirable neuropsychiatric side effects of ketamine. 

Denicoff KD, Rubinow DR, Papa MZ, Simpson C, Seipp CA, Lotze MT, Chang AE, Rosenstein D, Rosenberg SA. The neuropsychiatric effects of treatment with interleukin-2 and lymphokine-activated killer cells. Ann Intern Med 1987 107(3) 293-300. 

This is a central nervous system depressant licensed for the treatment of narcolepsy with cataplexy. At recommended doses, it has been associated with confusion, depression and other neuropsychiatric effects. Sodium oxybate is related to gamma hydroxybutyrate, a known drug of abuse, which has been associated with seizures, respiratory depression, coma and death. 

In addition to the acute toxic effects on the eyes, skin, and respiratory tract, both acute and longer-term neuropsychiatric effects (e.g. depression, anxiety, neurasthenia, insomnia, post-traumatic stress syndrome) have been documented for individuals exposed to sulfur mustard (Romano et al, 2008). Many of these effects have been documented for individuals exposed during noncombat (e.g. munitions plant workers) activities and are not always the result of high-level exposure that result in serious overt effects. Longer-term effects such as chronic bronchitis have been associated with occupational exposures that included episodes of acute toxicity, and delayed or recurrent keratitis may occur 8-40 years after a severe vapor exposure. Sulfur mustard-induced immunosuppression resulting in greater susceptibility to infections has also been reported. 

Continuous subcutaneous infusion of apomorphine can transform the quality of life of yoimger patients with severe motor fluctuations and dyskinesia, but this may lead to neuropsychiatric effects. If drug treatment fails in yormg non-demented patients, stereotactic subthalamotomy or bilateral stereotactic subthalamic stimulation can be very successful with only a small risk of surgical complications in experienced hands. Some 20% of patients with Parkinson s disease, notable the older ones, develop impairment of memory and speech with a fluctuating confusional state and hallucinations. As these symptoms are often aggravated by medication, it is... 

Exposure to CO results in a wide variety of potential adverse effects, particularly in individuals who have pre-existing cardiac or lung disease. Infants, the elderly, and the developing fetus are particularly vulnerable since they have less capacity to tolerate cardiovascular compromise. An additional problem is the delayed neurological and neuropsychiatric effects that have been documented after some significant exposures. The incidence of delayed neurotoxicity is between 2% and 30%. 

Flodin U, Ekberg K, Andersson L Neuropsychiatric effects of low exposure to styrene. 

Bolla KI, Schwartz BS, Agnew J, et al Subclinical neuropsychiatric effects of chronic low-level solvent exposure in US paint manufacturers. J Occup Med 32 671-677, 1990... 

Bowler RM, Mergler D, Sassine M-P, et al. 1999. Neuropsychiatric effects of manganese on mood. Neurotoxicology 20 367-378. 

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