Myostatin

Gregorio et al., 1998). T-cap in turn interacts in vitro with the stretch-dependent IsK ion channel (Furukawa et al., 2001), MLP (Knoll et al., 2002), and myostatin (Nicholas et al., 2002). The titin Zl-Z2/T-cap complex may function as a versatile adaptor complex that couple titin s N-terminus to myofibrillar signaling. 

Nicholas, G., Thomas, M., and Langley, B. (2002). Titin-cap associates with, and regulates secretion of, myostatin./ Cell. Physiol. 193, 120-131. 

Storage. Gravid proglottides should be stored in normal saline containing antibiotics, penicillin G (100 i.u./ml), streptomycin sulphate (100 / g/ml) and myostatin (100 fig/ml), as soon as possible after being passed. 

Carlson, C.J., F.W. Booth, and S.E. Gordon (1999). Skeletal muscle myostatin mRNA expression is fiber-type specific and increases during hindlimb unloading. Am. J. Physiol. 277 R601-R606. 

Suppresses neurogenesis through a myostatin-like pathway... 

Inhibits skeletal muscle growth interacts with Activin type I and II receptors suppresses myoblast proliferation by arresting cell cycle in G1 phase Binds to and inhibits myostatin ... 

Zhang TT, Sun L, Xin Y, Ma LX, Zhang YY, Wang X, et al. A vaccine grade of yeast Saccharomyces cerevisiae expressing mammahan myostatin. BMC Biotechnol 2012 12 97. 

Selective estrogen receptor modulators Other anti-estrogenic substances Agents modifying myostatin function Metabolic modulators... 

Intended for general treatment of muscle-fiber atrophy in aging and in several other settings, anti-myostatins are being developed as a new approach, but they have not yet become established for clinical use in any human muscle atrophy. 

Allen DL, Cleary AS, Hanson AM et al. (2010) CCAAT/enhancer binding factor-delta expression is increased in fast skeletal muscle by food deprivation and regulates myostatin transcription in vitro. Am J Physiol Regul Integr Comp Physiol 299, R1592-R1601. 

Allen DL, Loh AS. Post-transcriptional mechanisms involving microRNA-27a and b contribute to fast-specific and glucocorticoid-mediated myostatin expression in skeletal muscle. Am J Physiol Cell Physiol 300, C124-C137. 

Gonzalez-Cadavid NF, Taylor WE, Yarasheski K. et al. (1998) Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting. Proc Natl Acad Sci USA 95, 14938-14943. 

Jespersen JG, Nedergaard A Andersen LL et al. (2011) Myostatin expression during human muscle hypertrophy and subsequent atrophy increased myostatin with detraining. Scand J Med Sci Sports 21, 215-223. 

Kamanga-SoUo E, Pampusch MS, White ME et al. (2003) Role of insulin-like growth factor binding protein (IGFBP)-3 in TGF-beta- and GDF-8 (myostatin)-induced suppression of proliferation in... 

Ma K, Mallidis C, Bhasin S et al. (2003) Glucocorticoid-induced skeletal muscle atrophy is associated with upregulation of myostatin gene expression. Am J Physiol Endocrinol Metab 285, E363-E371. 

Welle S, Burgess K, Mehta S. (2009) Stimulation of skeletal muscle my ofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature mice. Am J Physiol Endocrinol Metab 296, B567-E572. 

Wojcik S, Nogalska A, Engel WK et al. (2008) Myostatin and its precursor protein are increased in the skeletal muscle of patients with Type-n muscle fibre atrophy. Folia Morphol (Warsz) 67, 6-12. 

Garcia PS, Cabbabe A, Kambadur R et al. (2010) Brief-reports elevated myostatin levels in patients with liver disease a potential contributor to skeletal muscle wasting. Anesth Analg 111, 707-709. 

Anderson SB, Goldberg AL, Whitman M. (2008) Identification of a novel pool of extracellular pro-myostatin in skeletal muscle. J Biol Chem 283, 7027-7035. 

Lenk K, Schur R, Linke A et al. (2009) Impact of exercise training on myostatin expression in the myocardium and skeletal muscle in a chronic heart failure model. Eur J Heart Pail 11, 342-348. 

Benny KlimekMB,AydogduT, LinkM.Jetal. (2010) Acute inhibition of myostatin-family proteins preserves skeletal muscle in mouse models of cancer cachexia. Biochem Biophys Res Commun 391, 1548-1554. 

Murphy KT, Cobani V, Ryall JG et al. (2011) Acute antibody-directed myostatin inhibition attenuates disuse muscle atrophy and weakness in mice. J Appl Physiol 110, 1065-1072. 

Castillero B, Nieto-Bona MP, Fernandez-Galaz C et al. (2011) Fenoflbrate, a PPAR alpha agonist, decreases atrogenes and myostatin expression and improves arthritis-induced skeletal muscle atrophy. Am J Physiol Endocrinol Metab 300, B790-B799. 

Gilson H, Schakman O, Combaret L et al. (2007) Myostatin gene deletion prevents glucocorticoid-induced muscle atrophy. Endocrinology 148, 452—460. 

Rodino-Klapac LR, Haidet AM, Kota J et al. (2009) Inhibition of myostatin with emphasis on follistatin as a therapy for muscle disease. Muscle Nerve 39, 283-296. 

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