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Murine monoclonals, antigenicity

Muronomab-CD3 is a murine monoclonal antibody directed against the CD3 complex of the T-lymphocyte antigen receptor. This drug selectively diminishes the T-lymphocyte pool resulting in a strong lymphopenia. Similar to other nonhuman antibodies the generation of human antimurine antibodies (HAMA) limits its long-term use. [Pg.619]

Mundegar RR, Franke E, Schafer R, et al. Reduction of high background staining by heating unfixed mouse skeletal muscle tissue sections allows for detection of thermostable antigens with murine monoclonal antibodies./. Histochem. Cytochem. 2008 56 969-975. [Pg.45]

Zevalin (Ibritumomab Tiuxetan murine monoclonal antibody, produced in a CHO cell line, targeted against the CD20 antigen) IDEC Pharmaceuticals Non-Hodgkin s lymphoma... [Pg.381]

Bexxar (tositumomab murine monoclonal raised against CD 20 surface antigen, found on the surface of B-lymphocytes) Corixa and GlaxoSmithKline Non-Hodgkin s lymphoma... [Pg.381]

NeutroSpec (murine monoclonal antibody raised against CD15 surface antigen of selected leukocytes) Palatin Technologies/ Mallinckrodt Inc. Imaging of equivocal appendicitis... [Pg.381]

Initial stages in the production of murine monoclonals entail administration of the antigen of interest to a mouse. This is followed by sacrifice and recovery of activated B-lymphocytes from the spleen. A similar approach to the production of human monoclonals would be unethical. Administration of some antigens to humans could endanger their health. Although B-lymphocytes could be obtained from the peripheral circulation, the majority of these are unstimulated, and recovery of (stimulated) B-lymphocytes from the spleen is impractical. [Pg.391]

The first monoclonals were murine (mouse) antibodies, because the early experiments involved injecting mice with an antigen, harvesting their B cells, and then fusing a harvested B cell with an immortal tumor cell line. There were immediate ahempts to make therapeutic drugs from murine monoclonal antibodies. Scientists at Harvard Medical School tried to apply murine monoclonal antibodies for heahnenf of tumors as early as 1980. But with a very few exceptions, murine antibodies failed as drugs in humans. [Pg.568]

CEA-scan (Arcitumomab, murine monoclonal antibody (Mab) fragment (Fab), directed against human carcinoembryonic antigen, CEA)... [Pg.416]

A. General description Muromonab-CD3 is a murine monoclonal antibody (MW 150 kDa) to the CD3 antigen of human T cells. It functions as an immunosuppressant. The antibody is a biochemically purified IgG2a immunoglobulin... [Pg.289]

Murine monoclonal antibody for cluster of differentiation 3 antigen [SY]... [Pg.517]

Capromab pendetide is a murine monoclonal antibody specific for prostate specific membrane antigen. It is coupled to isotopic indium (111In) and is used in immunoscintigraphy for patients with biopsy-confirmed prostate cancer and post-prostatectomy in patients with rising prostate specific antibody level to determine extent of disease. [Pg.1198]

Ping, L. H. and Lemon, S. M (1992) Antigenic structure of human hepatitis-A virus defined by analysis of escape mutants selected against murine monoclonal antibodies. J Virol 66,2208-2216... [Pg.171]

Described here is an indirect method for detecting two different cellular antigens in acetone-fixed tissue, using a rabbit polyclonal antibody, and a murine monoclonal antibody on the same section. One secondary antispecies antibody is conjugated with alkaline phosphatase, the other with peroxidase, thus resulting in two differently colored products showing the localization of the two antigens (Fig. 1). [Pg.271]

M2. Madaio, M. P., Carlson, J., Cataldo, J., Ucci, A., Migliorini, P., and Pankewycz, O., Murine monoclonal anti-DNA antibodies bind directly to glomerular antigens and form immune deposits. J. [Pg.165]

Murine monoclonal antibody binds to the CD3 antigen of T lymphocytes... [Pg.952]

Chimeric murine monoclonal antibody o binds to the CD20 antigen... [Pg.957]

See other pages where Murine monoclonals, antigenicity is mentioned: [Pg.276]    [Pg.376]    [Pg.384]    [Pg.391]    [Pg.394]    [Pg.569]    [Pg.411]    [Pg.421]    [Pg.428]    [Pg.434]    [Pg.306]    [Pg.1194]    [Pg.1198]    [Pg.119]    [Pg.119]    [Pg.134]    [Pg.297]    [Pg.141]    [Pg.145]    [Pg.220]    [Pg.230]    [Pg.113]    [Pg.483]    [Pg.208]    [Pg.209]    [Pg.405]    [Pg.456]    [Pg.590]   


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Antigenicity of murine monoclonals

Monoclonal murine

Murine

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