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Multivariable experiments

Determining the optimum parameters was a long process which required many hours of engineering and technician time and spanned a time period of over one year. In addition to these initial multivariant experiments, a large number of independent experiments were conducted to verify the predicted results. [Pg.206]

The method of steepest ascent was the first method by which multivariate experiments could be designed with a view to achieving a systematic improvement of the result. It was described by Box and Wilson[l] as early as 1951, and has been much used over the years, especially in industrial experimentation. The underlying principles are simple as can be seen in the following geometric illustration. [Pg.211]

Controlled multivariate experiments are the most logical, the most scientific, and the most efficient way that scientists know to collect data. Controlled experiments are the scientific... [Pg.91]

The purpose of the multivari chart is to discover the family of the red X, although on rare occasions the red X itself may become evident. The anticipated result of a successful multivari experiment is a set, the family, of possible causes that includes the red X, the pink Xs, or the pale pink Xs. The family will normally include possible causes numbering from a few up to about 20. Further experiments will be necessary to determine the red X or the pink Xs from this set. [Pg.2373]

The technique used to measure absorptive properties of fluff pulp systems containing different super absorbents was to perform multivariate experiments (of the Box Wilson type [1]) and fit a quadratic regression equation in the parameters studied. This procedure reduces the danger of drawing conclusions that are valid for only a narrow set of conditions which can occur when univariate experimental methods are used. [Pg.250]

The results obtained from the multivariate experiment, previously mentioned, showed that the absorption characteristics of diaper cores depended on the core density and the type and amount of SAP used in a complex manner. These experiments and the results will, therefore, be described in more detail. [Pg.252]

SAP performance in diaper cores in standard laboratory absorption tests did not correlate with end use performance because fluid loading in actual use is much less than in laboratory test procedures. A multivariate experiment with a thermally bonded fluff pulp system containing SAP showed that the mode of fluid absorption and retention shifted as the system density and SAP concentrations were changed. Maximum retention was achieved at low fluff density and high SAP concentration. [Pg.258]

Chatfield C and A J Collins 1980. Introduction to Multivariate Analysis. London, Chapman Hall. Dobson C M, A Sali and M Karplus 1998. Protein Folding A Perspective from Theory and Experiment. [Pg.574]

In the introduction to Part A we discussed the arch of knowledge [1] (see Fig. 28.1), which represents the cycle of acquiring new knowledge by experimentation and the processing of the data obtained from the experiments. Part A focused mainly on the first step of the arch a proper design of the experiment based on the hypothesis to be tested, evaluation and optimization of the experiments, with the accent on univariate techniques. In Part B we concentrate on the second and third steps of the arch, the transformation of data and results into information and the combination of information into knowledge, with the emphasis on multivariate techniques. [Pg.1]

DOSY is a technique that may prove successful in the determination of additives in mixtures [279]. Using different field gradients it is possible to distinguish components in a mixture on the basis of their diffusion coefficients. Morris and Johnson [271] have developed diffusion-ordered 2D NMR experiments for the analysis of mixtures. PFG-NMR can thus be used to identify those components in a mixture that have similar (or overlapping) chemical shifts but different diffusional properties. Multivariate curve resolution (MCR) analysis of DOSY data allows generation of pure spectra of the individual components for identification. The pure spin-echo diffusion decays that are obtained for the individual components may be used to determine the diffusion coefficient/distribution [281]. Mixtures of molecules of very similar sizes can readily be analysed by DOSY. Diffusion-ordered spectroscopy [273,282], which does not require prior separation, is a viable competitor for techniques such as HPLC-NMR that are based on chemical separation. [Pg.340]

Molina R, Martinez F, Melero JA, Bremner DH, Chakinala AG (2006) Mineralization of phenol by a heterogeneous ultrasound/Fe-SBA-15/H202 process multivariate study by factorial design of experiments. Appl Catal B Environ 66 198-207... [Pg.311]

There is an increasing need of understanding the reasons why some cancer patients respond to chemotherapy while others experience toxicity without any therapeutic benefit. Prospective large studies with multivariate analysis will be required to confirm the results of retrospective studies that, so far, have demonstrated associations between genetic defects and response. [Pg.302]

So, overall the chemometrics bridge between the lands of the overly simplistic and severely complex is well under construction one may find at least a single lane open by which to pass. So why another series Well, it is still our labor of love to deal with specific issues that plague ourselves and our colleagues involved in the practice of multivariate qualitative and quantitative spectroscopic calibration. Having collectively worked with hundreds of instrument users over 25 combined years of calibration problems, we are compelled, like bees loaded with pollen, to disseminate the problems, answers, and questions brought about by these experiences. Then what would a series named Chemometrics in Spectroscopy hope to cover which is of interest to the readers of Spectroscopy ... [Pg.2]

Cahn, F. and S. Compton, Multivariate Calibration of Infrared Spectra for Quantitative Analysis Using Designed Experiments , Applied Spectroscopy, 42 865-872 (July, 1988). [Pg.147]

We have shown a new concept for selective chemical sensing based on composite core/shell polymer/silica colloidal crystal films. The vapor response selectivity is provided via the multivariate spectral analysis of the fundamental diffraction peak from the colloidal crystal film. Of course, as with any other analytical device, care should be taken not to irreversibly poison this sensor. For example, a prolonged exposure to high concentrations of nonpolar vapors will likely to irreversibly destroy the composite colloidal crystal film. Nevertheless, sensor materials based on the colloidal crystal films promise to have an improved long-term stability over the sensor materials based on organic colorimetric reagents incorporated into polymer films due to the elimination of photobleaching effects. In the experiments... [Pg.92]

In optimization of a function of a single variable, we recognize (as for general multivariable problems) that there is no substitute for a good first guess for the starting point in the search. Insight into the problem as well as previous experience... [Pg.156]

Rieckmann and Volker fitted their kinetic and mass transport data with simultaneous evaluation of experiments under different reaction conditions according to the multivariate regression technique [116], The multivariate regression enforces the identity of kinetics and diffusivities for all experiments included in the evaluation. With this constraint, model selection is facilitated and the evaluation results in one set of parameters which are valid for all of the conditions investigated. Therefore, kinetic and mass transfer data determined by multivariate regression should provide a more reliable data basis for design and scale-up. [Pg.81]

Much effort has been devoted to the development of reliable calculation methods for the prediction of the retention behaviour of analyses with well-known chemical structure and physicochemical parameters. Calculations can facilitate the rapid optimization of the separation process, reducing the number of preliminary experiments required for optimization. It has been earlier recognized that only one physicochemical parameter is not sufficient for the prediction of the retention of analyte in any RP-HPLC system. One of the most popular multivariate models for the calculation of the retention parameters of analyte is the linear solvation energy relationship (LSER) ... [Pg.26]

Basic understanding and efficient use of multivariate data analysis methods require some familiarity with matrix notation. The user of such methods, however, needs only elementary experience it is for instance not necessary to know computational details about matrix inversion or eigenvector calculation but the prerequisites and the meaning of such procedures should be evident. Important is a good understanding of matrix multiplication. A very short summary of basic matrix operations is presented in this section. Introductions to matrix algebra have been published elsewhere (Healy 2000 Manly 2000 Searle 2006). [Pg.311]

This paper presents a method to decide the handling of seemingly Inconsistent data (outliers). The univariate and multivariate methods recommended are strongly based on statistics and the experience of the author In using them. [Pg.37]

The solvent-mediated transformation of o -L-glutamic acid to the S-form was quantitatively monitored over time at a series of temperatures [248]. The calibration model was built using dry physical mixtures of the forms, but still successfully predicted composition in suspension samples. Cornel et al. monitored the solute concentration and the solvent-mediated solid-state transformation of L-glutamic acid simultaneously [249]. However, the authors note that multivariate analysis was required to achieve this. Additionally, they caution that it was necessary to experimentally evaluate the effect of solid composition, suspension density, solute concentration, particle size and distribution, particle shape, and temperature on the Raman spectra during calibration in order to have confidence in the quantitative results. This can be a substantial experi-... [Pg.226]

The acoustic spectra were recorded simultaneously as other process experiments, in themselves not related to acoustic chemometrics, were carried out. This resulted in many days with stable conditions in the reactor, and no particular variations in the acoustic signals. Therefore there were only a limited number of days (hours) which displayed significant variation in process parameters, which are necessary for successful multivariate analysis and calibration. [Pg.287]


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See also in sourсe #XX -- [ Pg.150 ]




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Controlled multivariate experiments

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