Multiple stages of mass spectrometry

Mass Spectrometry, Mass Spectrometry/Mass Spectrometry, and Multiple Stages of Mass Spectrometry (MSn)... 

SA McLuckey, GL Glish, GJ Van Berkel. Multiple stages of mass spectrometry in a quadrupole ion trap mass spectrometer prerequisites. Int J Mass Spectrom Ion Processes 106 213—235, 1991. 

Selected Reaction Monitoring (SRM) Data acquired from specific product ions corresponding to m/z selected precursor ions recorded via two or more stages of mass spectrometry. Selected reaction monitoring can be preformed as tandem mass spectrometry in time or tandem mass spectrometry in space. The term multiple reaction monitoring is deprecated [1],... 

Cao P. and Stults J.T. (2000), Mapping the phosphorylation sites of proteins using on-line immobilized metal-ion affinity chromatography/capillary electrophore-sis/electrospray ionization multiple stage tandem mass spectrometry, Rapid Commun. Mass Spectrom. 14(17), 1600-1606. 

Carte, N., Cavusoglu, N., Leize, E., Van Dorsselaer, A., Charlet, M and Bulet, P. (2001) De novo sequencing by nano-electrospray multiple-stage tandem mass spectrometry of an immune-induced peptide of Drosophila melanogaster. Eur. J. Mass Spectrom. 7(4), 399 108. 

Y. Wada, M. Tajiri, and S. Yoshida, Hydrophilic affinity isolation and MALDI multiple-stage tandem mass spectrometry of glycopeptides for glycoproteomics, Anal. Chem., 76 (2004) 6560-6565. 

Van Setten DC, Zomer G, Van DeWerken G, Wiertz EJHJ, Leeflang BR, Kamerling JP (2000) Ion Trap Multiple-Stage Tandem Mass Spectrometry as a Pre-NMR Tool in the Structure Elucidation of Saponins. Phytochem Anal 11 190... 

Song FR, Cui M, Liu ZQ, Yu B, Liu SY (2004) Multiple-Stage Tandem Mass Spectrometry for Differentiation of Isomeric Saponins. Rapid Commun Mass Spectrom 18 2241... 

Tandem mass spectrometry (MS/MS), in its simplest and earliest implementations on quadrupole ion traps (QlTs), employed sequential (tandem-in-time MS/MS) isolation and energetic (for example, collisional) activation steps [16-22]. Modem MS/ MS experiments can involve multiple stages of mass selectivity (MS"), which employ different dissociation methods. Depending upon precursor chemistry, sometimes... 

It has been demonstrated also that the iTRAQ tandem mass spectrometric quantitative analysis strategy can be used in conjunction with the quadrupole ion trap by performing multiple stages of mass analysis (that is, MS ) [125], For example, chemical derivatization with the iTRAQ reagent not only labels the N-terminus of a peptide, but the lysine side chain also. Thus, tryptic peptides with a modified lysine residue present at the C-terminus will produce a yj product ion at m/z 291 following ClD-tandem mass spectrometry. To generate the low m/z iTRAQ reporter ions required for quantitation, the yj product ion is isolated and subjected to data-dependent CID-MS. Using this approach, peptide identification is achieved in the MS/MS scan, while quantitation is achieved via MS. ... 

Song F, Cui M, Liu Z, Yu B, Liu S. Multiple-stage tandem mass spectrometry for differentiation of isomeric saponins. Rapid Commun Mass Spectrom. 2004 18 2241-8. 

Eberlin, M.N., Kotiaho, T., Shay, B.J. et al. (1994) Gas-phase C1+ affinities of pyridines determined by the kinetic method using multiple-stage (MS3) mass spectrometry. J. Am. Chem. Soc., 116, 2457-2465. 

Multiple-Stage Mass Spectrometry (MS") Multiple stages of precursor ion m/z selection followed by product ion detection for successive progeny ions. 

MS" NIH NIST multiple stages of tandem mass spectrometry National Institute of Health (USA) National Institute of Standards and Technology (USA)... 

P. J., Kelly, M. A., Schriemer, D. C. Frontal affinity chromatography-mass spectrometry assay technology for multiple stages of drug discovery applications of a chromatographic... 

Tandem mass spectrometry, more commonly known as MS-MS, utilises multiple stages of analysis. It is very selective and provides useful structural information. A variety of scan modes can be used to provide specific information for structural... 

Multiple stages (n) of mass spectrometry in sequence Nonaqueous capillary zone electrophoresis Nitrogen-phosphorus detector Quadrupole/time-of-flight analyzer Relative standard deviation... 

Stacey, C. Phillips, R. Specific Compound Identification Using Multiple Stages of Fragmentation With and ESI-Ion Trap," in Proceedings of the 45th ASMS Conference on Mass Spectrometry and Allied Topics, Palm Springs, California, June 1-5, 1997. 

In principle, both instrumental concepts can be expanded to allow for multiple-stage mass spectrometry, i.e., multiple stages of precursor ion selection followed by product ion detection for successive n generation product ions [6]. While it is convenient to talk about MS/MS, acronyms like MS/MS/MS are clearly out of place. Therefore, it is common practice to use MS, MS, and generally MS" to denote the number of stages of a tandem mass spectrometric experiment. Accordingly, in the sequential fragmentation scheme... 

The ability to perform multiple stages of MS/MS makes FTMS a powerful tool for the characterization of complex molecules. Typically, tandem mass spectrometry is performed using ESI-FTMS and M ALDl-FTMS, but dissociation techniques that reduce precursor ion charge (e.g., ECD, ETD, and EDD) must be performed on multiply charged ions and are therefore used with ESI. 

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