Drug discovery applications

Drug discovery applications also provide insights for the eventual determination of the compounds in a forensic or toxicological setting this is another area in which multidimensional chromatography allows the direct injection of bodily fluids. For... 

Chovan, L.E. et al. 2004. Automatic mass spectrometry method development for drug discovery Application in metabolic stability assays. Rapid Commun. Mass Spectrom. 18 3105. 

Hans-Joachim Bohm and Martin Stahl, The Use of Scoring Functions in Drug Discovery Applications. 

Biological Profiling/Fingerprints and Drug Discovery Applications... 

Bohm, H.-J. and Stahl, M. The use of scoring functions in drug discovery applications. Rev. Comput. Chem. 2002, 38,41-87. 

P. J., Kelly, M. A., Schriemer, D. C. Frontal affinity chromatography-mass spectrometry assay technology for multiple stages of drug discovery applications of a chromatographic... 

Xu, X. Zhou, Q. Korfmacher, W. A. Development of a low volume plasma sample precipitation procedure for liquid chromatography/tandem mass spectrometry assays used for drug discovery applications. Rapid Commun Mass Spectrom 2005, 19, 2131-2136. 

Ekins, S., Mestres, J., Testa, B. In silico pharmacology for drug discovery applications to targets and beyond. Br. J. Pharmacol. 2007, 152, 21-37. 

Cai, Z., Han, C., Harrelson, S., Fung, E., and Sinhababu, A. K. (2001). High-throughput analysis in drug discovery Application of liquid chromatography/ion-trap mass spectrometry for simultaneous cassette analysis of alpha-la antagonists and their metabolites in mouse plasma. Rapid Commun. Mass Spectrom. 15 546-550. 

Although CHCA works well with most drug molecules, there is no universal MALDI matrix. However, as with the internal standard, it is not practical to optimize matrix selection for each compound in broad drug discovery applications. 

The key feature of DCC is the reversible chemical reaction that mediates exchange of the building block fragments.117-91 For in situ drug discovery applications of DCC, the selection of linked fragments occurs in the same environment as the equilibration reaction and this demands that the reaction fulfils several requirements in addition to... 

Reddy G, Dalmasso EA. SELDI ProteinChip(R) array technology protein-based predictive medicine and drug discovery applications. J Biomed Biotechnol 2003 2003 237-241. 

Bohm HJ, Stahl M. The use of scoring function in drug discovery applications. In Lipkowitz KB, Boyd DB, eds. Reviews in Computational Chemistry, vol 18. Weinheim, Germany Wiley VCH, 2002 41-87. 

As a still evolving discipline, chemoinformatics is an equally interesting playground for method development, chemical and drug discovery applications, and interdisciplinary research. This makes this field a rather exciting area to work in and it is hoped that the information provided herein might encourage many scientific minds to actively contribute to its further development. 

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