Multiple chemical sensitivity chronic fatigue syndrome

Pall ML, Satterlee JD. Elevated nitric oxide/peroxynitrite mechanism for the common etiology of multiple chemical sensitivity, chronic fatigue syndrome and posttraumatic stress disorder. Ann NY Acad Sci 2001 933 323-9. 

Dr. Martin Pall of Washington State University uncovered the neurological biochemical processes that underlie MCS, and demonstrated a link to processes that are also relevant to chronic fatigue syndrome. He described the increased permeability of the blood-brain barrier as a result of exposure to certain substances and as a result of increased peroxynitrite level. The more this barrier disintegrates, the more chemical substances are able to directly enter the brain and the more sensitive a person becomes. Increased levels of nitric oxide in the body in turn influence the enzymes responsible for breaking down chemical substances (P450 enzyme). He published an article about his model, tide Elevated Nitric Oxide/Per-oxynitrite Theory of Multiple Chemical Sensitivity Central Role of N-Methyl-d-Aspartate Receptors in the Sensitivity Mechanism, in Environmental Health Perspectives. It can be read online at www.ehponline.org/members/ 2003/5935/5935.html. 

Explaining Unexplained Illnesses Disease Paradigm for Chronic Fatigue Syndrome, Multiple Chemical Sensitivity... 

Multiple Chemical Sensitivity (MCS) and Chronic Fatigue Syndrome (CFS)... 

Chemical Sensitivity Multiple Chemical Sensitivity (MCS), Chronic Fatigue Syndrome (CFS), Fibromyalgia (FM), and Gulf War Syndrome (GWS)... 

Individuals with chemical sensitivity, also referred to as chemical intolerance, are those who react adversely to low levels of chemicals that are tolerated by the general population. These include Multiple Chemical Sensitivity (MCS), Chronic Fatigue Syndrome (CFS), Fibromyalgia (FM), and Gulf War Syndrome (GWS). Each is a clinically defined condition that can give rise to chemical sensitivity, but there is, however, considerable comorbidity between them. Each is addressed individually, followed by a discussion of its similar responses to chemical stimuli. 

As can be seen from this list of symptoms, many are emblematic of multiple chemical sensitivity and chronic fatigue syndrome. This crossover of symptoms often complicates the diagnosis of FM. Mechanistically, oxidative stress and nitric oxide are believed to play a role in FM pathophysiology however, it is not clear at this time whether the oxidative stress abnormalities found in FM are the cause or the effect J46 59 ... 

Pall ML. Common etiology of posttraumatic stress disorder, fibromyalgia, chronic fatigue syndrome and multiple chemical sensitivity via elevated nitric oxide/peroxynitrite. Med Hypotheses 2001 57(2) 139-45. 

Reid S, Hotopf M, Hull L, et al. Multiple chemical sensitivity and chronic fatigue syndrome in British Gulf War veterans. Am J Epidemiol 2001 153(6) 604-9. 

Jason LA, Taylor RR, Kennedy CL. Chronic fatigue syndrome, fibromyalgia and multiple chemical sensitivities in a community-based sample from persons with chronic fatigue-like symptoms. Psychosomatic Med2000 62 655-63. 

Brown MM, Jason, LA. Functioning in individuals with chronic fatigue syndrome Increased impairment with co-occurring multiple chemical sensitivity and fibromyalgia. Dyn Med 2007 6(1) 6, www.dynamic-med.com/ content/6/1/6... 

Buchwald D, Garrity D. Comparison of patients with chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities. Arch Intern Med 1994 154(18) 2049-53. 

The cultural pattern of illnesses in the Francophone world also differs from that in the English-speaking world. Illness entities such as chronic fatigue syndrome or multiple chemical sensitivity are hardly acknowledged (Mouterde, 2001 Girault, 2002). 

Guglielmi RS, Cox D], Spyker DA Behavioral treatment of phobic avoidance in multiple chemical sensitivity. ] Behav Ther Exp Psychiatry 25 197-209, 1994 Gupta K, Horne R The influence of health beliefs on the presentation and consultation outcome in patients with chemical sensitivities. J Psychosom Res 50 131-137,2001 Haller E Successful management of patients with multiple chemical sensitivities on an inpatient psychiatric unit. ] Clin Psychiatry 54 196-199, 1993 Jason LA, Taylor RR, Kennedy CL Chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities in a community-based sample of persons with chronic fatigue syndrome-like symptoms. Psychosom Med 62 655-663, 2000 Kaplan BJ, McNicol J, Conte RA, et al Dietary replacement in preschool-aged hyperactive boys. Pediatrics 83 7-17, 1989... 

Fiedler N, Kipen HM, Deluca J, et al A controlled comparison of multiple chemical sensitivities and chronic fatigue syndrome. Psychosom Med 58 38-49, 1996 Giardino ND, Lehrere PM Behavioral conditioning and idiopathic environmental intolerance. Occup Med 15 519-528, 2000... 

Chester AC, Levine PH The natural history of concurrent sick building syndrome and chronic fatigue syndrome. J Psychiatr Res 31 51-57,1997 Cone J, Suit TA Acquired intolerance to solvents following pesticide/solvent exposure in a building a new group of workers at risk for multiple chemical sensitivities. Toxicol Ind Health 8 29-39,1992... 

Consideration of environmental diseases , e.g., siek building syndrome, chronic fatigue syndrome, multiple chemical sensitivity syndrome. 

There were many nonspecific illnesses, or syndromes, that emerged in the late twentieth century. Despite, or perhaps because of, their proliferation, they are usually controversial. All have in common either a lack of identifiable cause or a diversity of expression, or both. In addition to sick building syndrome and multiple chemical sensitivity, nonspecific Ulnesses include Gulf War syndrome, chronic fatigue syndrome, acquired immunodeficiency syndrome, cumulative trauma disorder (also called repetitive strain injury), and a host of psychological disorders. 

---