Multifunctional biomaterials

Surface modification is one of the most important technologies for the preparation of multifunctional biomaterials. Surface modification techniques include coating, blending, and grafting. 

Multifunctional biomaterials and their bioinspired systems for bioactive molecules delivery... 

This chapter will discuss multifunctional biomaterials inspired by biological systems directed at influencing tissue cells and miCToorganisms, separately, or a combination of both, by delivery of bioactive molecules. Delivery is here considered in the broad sense of the word, as materials can contain biomolecules that are released when appropriate, but also merely present the biomolecules at the target site. As the field of biomaterials and their related functions has expanded beyond comprehension, a selection of relevant and recent studies will be discussed to underline the importance of multifunctional materials. 

The first topic is composed by six chapters that present a general overview and discuss sensitive subjects such as Design and preparation of biomimetic and bioinspired materials, Preparative methods and devices of bioinspired materials in drug-delivery systems, Metamorphic biomaterials. Molecular signaling mechanisms of host-materials interactions. Multifunctional biomaterials and their bioinspired systems for bioactive molecules delivery, and the Perspectives of bioinspired materials in regenerative medicine. 

Biomaterials such as proteins/enzymes or DNA display highly selective catalytic and recognition properties. Au nanoparticles or nanorods show electronic, photonic and catalytic properties. The convergence of both types of materials gives rise to Au NP-biomolecule hybrids that represent a very active research area. The combination of properties leads to the appearance of biosensors due to the optical or electrical transduction of biological phenomena. Moreover, multifunctional Au NP-peptide hybrids can be used for targeting nuclear cells where genetic information is stored and could be useful for biomedical applications [146]. 

Andersson,., Areva, S., Spliethoff, B., and Linden, M. (2005) Sol-gel synthesis of a multifunctional, hierarchically porous silica/apatite composite. Biomaterials, 26 (34), 6827-6835. 

W. Yuan, J. Ji, J. Fu, J. Shen, A facile method to construct hybrid multilayered films as a strong and multifunctional antibacterial coating . Journal of Biomedical Materials Research Part B Applied Biomaterials, 852,556-563, (2007). 

Nichfor, M., Constantin, M., Macanu, G., Fundueanu, G., Branisteanu, D., 2009. New multifunctional textile biomaterials for treatment of leg venous insufficiency. Journal of Material Science Materials in Medicine 20975—20982. 

D.A. Wang, S. Varghese, B. Sharma, I. Strehin, S. Fermanian, J. Gorham, et al.. Multifunctional chondroitin sulphate for cartilage tissue-biomaterial integration, Nat. Mater. 6 (5) (2007) 385-392. 

S. Wen, et al.. Multifunctional dendrimer-entrapped gold nanoparticles for dual mode CT/MR imaging appUcations, Biomaterials 34 (5) (2013) 1570-1580. 

Acrylic monomers and oligomers, multifunctional hydrophilic and hydrophobic. See Multifunctional hydrophilic and hydro-phobic acrylic monomers and oligomers Adhesion, biomaterials, 45,46/... 

Zhang Q, Mochalin VN, Neitzel 1, Hazeli K, Niu J, Kontsos A, et al. Mechanical properties and biomineralization of multifunctional nanodiamond-PLLA composites for bone tissue engineering. Biomaterials 2012 33 5067-75. 

Amitai, G., Murata, H., Andersen, J. D., Koepsel, R. R. and Russell, A. J. 2010. Decontamination of chemical and biological warfare agents with a single multifunctional material. Biomaterials, 31,4417-25. 

Surface modification of polymeric biomaterials is becoming an increasingly popular method to improve material multifunctional, biological... 

Keywords Controlled drug release Shape-memory polymer Multifunctional material Biodegradable polymer Biomaterial... 

Blazewicz S (2006) Non-metalic multifunctional composites in biomaterials engineering. In Nadolny AJ (ed) Biomaterials in regenerative medicine. Polish Academy of Sciences, Warszawa... 

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