Bioactive molecule delivery

Research focused on the application of PNC scaffolds for BTE (PNC-BT scaffolds) has shown their great potential as a single platform with multifunctional capabilities for bone regeneration emerging as an attractive approach. PNC-BT scaffolds with the added value of bioactive molecule-delivery capability appear particularly promising. 

Multifunctional biomaterials and their bioinspired systems for bioactive molecules delivery... 

This chapter will discuss multifunctional biomaterials inspired by biological systems directed at influencing tissue cells and miCToorganisms, separately, or a combination of both, by delivery of bioactive molecules. Delivery is here considered in the broad sense of the word, as materials can contain biomolecules that are released when appropriate, but also merely present the biomolecules at the target site. As the field of biomaterials and their related functions has expanded beyond comprehension, a selection of relevant and recent studies will be discussed to underline the importance of multifunctional materials. 

The first topic is composed by six chapters that present a general overview and discuss sensitive subjects such as Design and preparation of biomimetic and bioinspired materials, Preparative methods and devices of bioinspired materials in drug-delivery systems, Metamorphic biomaterials. Molecular signaling mechanisms of host-materials interactions. Multifunctional biomaterials and their bioinspired systems for bioactive molecules delivery, and the Perspectives of bioinspired materials in regenerative medicine. 

Young S, Wong M, Tabata Y et al (2005) Gelatin as a delivery vehicle for the controlled release of bioactive molecules. J Control Release 109 256-274... 

Transferosomes represent another system of encapsulation using ultradeformable vesicle carriers for bioactive molecules, applied until now for direct transdermal drug delivery. They are built from polar lipids and have high flexibility, and are rich in unsaturated fatty acids and carotenoid pigments." ... 

Halloysite Nanotubules, a Novel Substrate for the Controlled Delivery of Bioactive Molecules... 

Figure 2 Schematic overview of membrane potential-based strategies for the targeted delivery of bioactive molecules to mitochondria in living mammalian cells.

Smith RA, Porteous CM, Gane AM, Murphy MP. Delivery of bioactive molecules to mitochondria in vivo. Proc Natl Acad Sci USA 2003 100(9) 5407-5412. 

The inclusion into the hydrophobic cavity causes modifications of solubility, bioavailability, and delivery properties of many bioactive molecules. Furthermore the stability of many guest molecules is improved, e.g., against... 

Due to their highly biocompatible nature, dendritic PGs have a broad range of potential applications in medicine and pharmacology. The versatility of the polyglycerol scaffolds for application in the biomedical field has recently been reviewed [131], and a number of examples were described, therein, e.g., smart and stimuli-responsive delivery and release of bioactive molecules, enhanced solubilization of hydrophobic compounds, surface-modification and regenerative therapy, as well as transport of active agents across biological barriers (cell-membranes, tumor tissue, etc.). 

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