Lead, properties

D. E. Enhancing the hit-to-lead properties of lead optimization libraries. 

The use of pharmacophoric descriptors in enhancing the hit-to-lead properties of lead optimization libraries has been described (76). Pharmacophore fingerprints, based on the Chem-X/ChemDiverse multiple pharmacophore descriptors, were used and several issues in the design of lead optimization libraries were addressed. The applicability of... 

Pickett, S.D., McLay, I.M. and Clark, D.E. (2000) Enhancing the hit-to-lead properties of lead optimization libraries. Journal of Chemical Information and Computer Sciences, 40, 263-272. 

The discussion of lead properties of course does not apply to leadless devices such as leadless ceramic chip carriers (LCCCs). Design teams using these and similar packages must understand the better heat transfer properties of the alumina used in ceramic packages and must match coefficients of thermal expansion (CTEs or TCEs) between the LCCC and the substrate since there are no leads to bend and absorb mismatches of expansion. Use of ceramic devices may lead the design team to consider the use of Low Temperature Co-fired Ceramic (LTCC) substrates and assembly technologies XXX. 

Nakheel Nakheel, one of the United Arab Emirates s leading property developers,... 

Organisation for Economic Co-operation and Development — Nuclear Energy Agency, 2015. Handbook on Lead-Bismuth Eutectic Alloy and Lead Properties, Materials Compatibility, Thermal-Hydraulics and Technologies — 2015 edition. NBA No.7268, 954 pp. 

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