Hybrid peptides

N-H--0) are 149.7° (inner H-bond) and 144.7° (outer H-bond). (B) Hybride -peptide 120 with a D-Pro-Gly type IT -turn segment (gray color) X-ray crystal structure [192]. The intramolecular H-bond N---0 distances are shown. The angles (N-H---0) are 147° (inner H-bond) and 155° (outer H-bond). The inter-molecular NH-0=C H-bonds (with N-H -O angles of 160 and 133 °) connect the hairpin into an infinitely extended -sheet... 

Du, L., Sanchez, C. andShen, B. (2001) Hybrid peptide—polyketide natural products biosynthesis and prospects toward engineering novel molecules. Metabolic Engineering, 3 (1), 78—95. 

Kohli, R.M., Burke, M.D., Tao, J. and Walsh, C.T. (2003) Chemoenzymatic route to macrocyclic hybrid peptide/ polyketide-like molecules. Journal of the American Chemical Society, 125, 7160-7161. 

Ferre R, Badosa E, Feliu L, Planas M, Montesinos E, Bardaji E (2006) Inhibition of plant-pathogenic bacteria by short synthetic cecropin A-melittin hybrid peptides. Appl Environ Microbiol 72 3302-3308... 

Scheme 7.10 Enzymatic macrocyclization to create novel hybrid peptide/PKs.

Shen B, Du L, Sanchez C, Chen M and Edwards DJ (1999) Bleomycin biosynthesis in Streptomyces ver-ticillus ATCC15003 a model of hybrid peptide and polyketide biosynthesis. Bioorg Chem 27, 155-171. 

S Doekel, MA Marahiel. Dipeptide formation on engineered hybrid peptide synthetases. Chem Biol 7 373-384, 2000. 

Du L, Shen B. Biosynthesis of hybrid peptide-polyketide natural products. Curr. Opin. Drug Discov. Devel. 2001 4 215-228. 

Roy RS, Balaram P. Conformational properties of hybrid peptides containing a- and (u-amino acids. J. Pept. Res. 2004 63 279-289. 

Baldauf C, Gunther R, Hofmann HI. Helix formation in a,y- and P,y-hybrid peptides theoretical insights into mimicry of a- and P-peptides. J. Org. Chem. 2006 71 1200-1208. 

Abstract This article summarizes recent developments in the synthesis of polypeptides and hybrid peptide copolymers. Traditional methods used to polymerize -amino acid-N-carboxyanhydrides (NCAs) are described, and limitations in the utility of these systems for the preparation of polypeptides are discussed. Recently developed initiators and methods are also discussed that allow polypeptide synthesis with good control over chain length, chain length distribution, and chain-end functionality. The latter feature is particularly useful for the preparation of polypeptide hybrid copolymers. The methods and strategies for the preparation of such hybrid copolymers are described, as well as analysis of the synthetic scope of the different methods. Finally, issues relating to obtaining these highly functional copolymers in pure form are detailed. 

R. Kohli, M. Burke, J. Tao, C. Walsh, Chemoenzymatic route to macrocyclic hybrid peptide/polyketide-like molecules, J. Am. Chem. Soc. 2003,... 

Du L, Sanchez C, Shen B (2001). Hybrid peptide—polyketide natural products Biosynthesis and prospects towards engineering novel molecules. Metab. Eng. 3 78-95. 

The gene cluster cloned and characterized from S. verticillus ATCC 15003 for BLM is considered the model for hybrid peptide PKSs [365], BLM is an... 

Piets KL, Hancock REW. The interaction of a recombinant cecropinfmelittin hybrid peptide with the outer membrane of Pseudomonas aeruginosa. Mol Microbiol 1994 12 951-958,... 

Sipos D, Chandrasekhar K, Arvidsson K, Engstrom A, Ehrenberg A. Two dimensional pio-ton-NMR studies on a hybrid peptide between cecropin A and melittin. Resonance assign-ments and secondary structure, bur J Biochem 1991 199 285-291. 

A. Gaowa, T. Horibe, M. Kohno, K. Sato, H. Harada, M. Hiraoka, Y. Tabata, and K. Kawakami, Combination of hybrid peptide with biodegradable gelatin hydrogel for controlled release and enhancement of anti-tumor activity in vivo, /. Control. Release, 176, 1-7, 2014. 

R., Lew, R., Rossjohn, J., Smith, A.L, and Perlmutter, P. (2007) P-Amino acid-containing hybrid peptides -new opportunities in peptidomimetics. Org. Biomol. Chem., 5, 2884-2890. 

C. Sanchez, L.C. Du, D.J. Edwards, M.D. Toney, B. Shen, Cloning and characterisation of a phosphopantetheinyl transferase from Streptomyces verticillus ATCC15003, the producer of the hybrid peptide-polyketide antitumor drug bleomycin. Chem. Biol. 8, 725-738 (2001)... 

In the following, we first discuss the substrate specificity of heteropolymer adhesion by employing a simple hybrid lattice model [284, 303, 306, 309, 318]. After having gained this qualitative insight into the structural binding behavior of heteropolymers, an exemplary realistic hybrid peptide-semiconductor system is investigated to verify the sequence specificity of peptide adsorption [274-276,340]. 

Katritzky, A. R. Abdelmajeid, A. Tala, S. R. Amine, M. S. Steel, R J. Novel fluorescent aminoxy acids and aminoxy hybrid peptides. Synthesis 2011,83-90. 

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