Mucosa-associated lymphoid tissues MALT

Lymphomas not included in Working Formulation mycosis fungoides, mantle cell lymphoma, monocytoid B-cell lymphoma, mucosa-associated lymphoid tissue (MALT), anaplastic large cell lymphoma, angiocentric lymphoma, angioimmunoblastic lymphadenopathy (AILD), Castleman s disease, adult T-cell leukemia/lymphoma. 

H. pylori is one of the main causes of human chronic gastritis, resulting in various diseases including peptic ulcers, gastric adenocarcinomas, and mucosa-associated lymphoid tissue (MALT) lymphomas (Williams... 

Isaacson, P. G., Muller-Hermelink, H. K., Piris, M. A., Berger, F., Nathwani, B., Swerdlow, S. H., and Harris, N. L., Extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma). In World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues (E. S. Jaffe, N. L. Harris, H. Stein, and J. W. Vardiman, eds.), pp. 157-160. IARC Press, Lyon, 2001. 

W11. Wotherspoon, A. C., Doglioni, C., and Isaacson, P. G., Low-grade gastric B-cell lymphoma of mucosa-associated lymphoid tissue (MALT) A multifocal disease. Histopathology 20, 29-34 (1992). 

The organs of the body which comprise the immune system and/or contribute to immune function include the bone marrow, spleen, thymus, lymph nodes, a network of lymphoid tissue along secretory surfaces (i.e., the so-called mucosa-associated lymphoid tissue, MALT), and the skin. Lymphoid organs can be classified in two ways. The first classification is based on the role that organs play in the development of the immune system and/or its ability to elicit a response. 

FIGURE 33-2. The natural history of Helicobacter pylori infection in the pathogenesis of gastric ulcer and duodenal ulcer, mucosa-associated lymphoid tissue (MALT) lymphoma, and gastric cancer. 

Mucosa-associated lymphoid tissue (MALT) lymphoma... 

EXTRANODAL MARGINAL ZONE B-CELL LYMPHOMA OF MUCOSA-ASSOCIATED LYMPHOID TISSUE (MALT) TYPE... 

Morgan JA, Yin Y, Borowsky AD et al (1999) Breakpoints of the t( 11 18)(q21 q21) in mucosa-associated lymphoid tissue (MALT) lymphoma lie within or near the previously undescribed gene MALT1 in chromosome 18. Cancer Res 59(24) 6205-6213... 

Gastric adenocarcinoma is one of the leading causes of cancer morbidity and mortality worldwide. Gastric cancer comprises approximately 95% of all gastric tumors, and is the focus of this chapter. Other less common gastric tumors not discussed here include mucosa-associated lymphoid tissue (MALT) lymphoma, gastrointestinal stromal cell tumors, and carcinoid tumors. 

In analogy with the mucosa-associated lymphoid tissue [MALT], SALT would work as a specific sentinel for invading pathogens. In this context, skin would play not only a barrier role but also be a component of the lymphatic system. Therefore,... 

LIP is part of a spectrum of pulmonary lymphoid proliferations that includes follicular bronchitis/bronchioUtis, NLH, and MALT B-cell lymphoma (4,5). They can be difficult to differentiate from each other (5,6). Indeed, a substantial percentage of the cases that were initially classified by Averill Liebow (3) as LIP were subsequently found to be mucosa-associated lymphoid tissue (MALT) lymphomas. As a result, LIP was excluded from the classification of idiopathic interstitial pneumonias for several decades. Today, it is clear that the majority of patients with LIP have associated immunologic disorders, dysproteinemias or viral infections, so that LIP can be viewed as a morphologic pattern of lung injury that results from multiple causes with varying pathogenetic mechanisms rather than a distinct disease entity (1). However, a few cases of LIP do present as idiopathic disease. LIP therefore is still included in recent classifications of idiopathic interstitial pneumonias (7). 

Low-grade gastric mucosa-associated lymphoid tissue (MALT) lymphoma accounts for the majority of primary gastric lymphomas (50%-72%) (Yoo et al. 1998). They are associated with H. pylori infection and are shown to regress completely following... 

Kessar P, Norton A, Rohatiner AZ, Lister TA, Reznek RH (1999) CT appearances of mucosa-associated lymphoid tissue (MALT) lymphoma. Eur Radiol 9 693-696 Kinkel K, Lu Y, Both M, Warren RS, Thoeni RE (2002) Detection of hepatic metastases from cancers of the gastrointestinal tract by using non-invasive imaging methods (US, CT, MR imaging, PET) a meta-analysis. Radiology 224 748-756... 

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