Pathogenetic mechanisms

Chang, L.W. 1986. Neuropathology of trimethyltin a proposed pathogenetic mechanism. Fundam. Appl. Toxicol. 6 217-232. 

There are two forms of idiopathic inflammatory bowel disease (IBD) ulcerative colitis, a mucosal inflammatory condition confined to the rectum and colon, and Crohn s disease, a transmural inflammation of GI mucosa that may occur in any part of the GI tract. The etiologies of both conditions are unknown, but they may have a common pathogenetic mechanism. 

This book tells the story of the ubiquitin system as we currently know it from the regulation of basic cellular processes to quality control and the pathogenetic mechanisms of disease, from X-ray crystallography of the 26S proteasome to the interaction between substrates and their ligases, to the development of mechanism-based drugs, and to target-specific aberrant processes. 

Modell, J.G., Mountz, J.M., Curtis, G.C., and Greden, J.E (1989) Neurophysiologic dysfunction in basal ganglia/limbic striatal and thalamocortical circuits as a pathogenetic mechanism of obsessive-compulsive disorder. / Neuropsychiatry Clin Neurosci 1 27-36. 

Hornig-Rohan M, Amsterdam JD Clinical and biological correlates of treatment-resistant depression an overview. J Clin Psychiatry 24 220-227, 1994 Horowski R, Wachtel L, Turski L, et al Glutamate excitotoxicity as a possible pathogenetic mechanism in chronic neurodegeneration, in Neurodegenerative Diseases. Edited by Caine DB. Philadelphia, PA, WB Saunders, 1994, pp 163-174... 

Several cases of severe metabolic acidosis after recreational toluene sniffing have been described renal tubule damage has been proposed as the pathogenetic mechanism (Batlle et al., 1988 Goodwin, 1988 Pearson et al., 1994 Hong et al., 1996). 

McIntosh T. K., Saatman K. E., Raghupathi R., Graham D. I., Smith D. H., Lee V. M., and Trojanowski J. Q. (1998). The molecular and cellular sequelae of experimental traumatic brain injury pathogenetic mechanisms. Neuropathol. Appl. Neurobiol. 24 251-267. 

Hattori N, Mizuno Y. Pathogenetic mechanisms of parkin in Parkinson s disease. Lancet. 2004 3 64 722-724. 

One of the major difficulties in identifying potential biomarkers related to AD is likely a result of the fact that specific proteins involved in the pathogenetic mechanisms are low abundant in CSF and serum, while a small number of proteins such as albumin, transferrin, and immunoglobulins provide a significant background that makes it difficult to identify low-abundance proteins. 

A wide spectrum of adverse reactions may occur after ingestion of food. Adverse food reactions can be divided on the basis of immunologic and nonimmunologic pathogenetic mechanisms (Johansson et al., 2001 Sicherer, 2002). 

In summary, important advances have been made in our understanding of the underlying pathogenetic mechanism in spinal cord ischemia. This condition remains a diagnostic and therapeutic challenge, but improved diagnosis may result in better treatment in the future. 

The aforementioned reactions are thought to involve the following pathogenetic mechanisms. 

Jiang JP, Downing SE. Catecholamine cardiomyopathy review and analysis of pathogenetic mechanisms. Yale J Biol Med 1990 63(6) 581-91. 

Samuelsson M, Lindell D, Norrving B (1996). Presumed pathogenetic mechanisms of recurrent stroke after lacunar infarction. Cerebrovascular Diseases 6 128-136 Sanna G, Bertolaccini ML, Hughes GR (2005). Hughes syndrome the antiphosphoUpid syndrome a new chapter in neurology. Annals of the New York Academy of Sciences 1051 465-486... 

Hepatic storage disease (J. Golan et at, 1985) is deemed to be a variant of Rotor syndrome. This dysfunction is witnessed during the first years of life. Bilirubin values are only moderately elevated (2—4 mg/dl). About half of the bilirubin is conjugated. The pathogenetic mechanisms are presumably the same as in Rotor syndrome. Treatment is likewise not required for this benign disorder. 

The frequent coexistence of the hepatorenal syndrome, ascites and/or hepatic encephalopathy suggests that similar pathogenetic mechanisms are responsible for these three intricate developments. 

Bleeding oesophageal varices may be triggered by three pathogenetic mechanisms (7.) critical pressure increase in the varices, especially when it is sudden (= explosion hypothesis), (2.) occurrence of flow turbulences with bidirectional blood flow in the varices (= circulation hypothesis), and (5.) inflammatory lesion at the varix surface with the formation of thin spots (= erosion hypothesis). 

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