MRSA Action

MRSA Action UK - founded by a group of people who all had life changing experiences or lost a loved one through contracting MRSA - all volunteers who share a common purpose - to relieve the distress and suffering experienced by patients who contract healthcare infections. 

An additional disadvantage with many penicillin and cephalosporin antibiotics is that bacteria have developed resistance to the drugs by producing enzymes capable of hydrolysing the P-lactam ring these enzymes are called P-lactamases. This type of resistance still poses serious problems. Indeed, methicillin is no longer used, and antibiotic-resistant strains of the most common infective bacterium Staphylococcus aureus are commonly referred to as MRSA (methicillin-resistant Staphylococcus aureus). The action of P-lactamase enzymes resembles simple base hydrolysis of an amide. 

Mupirocin (Bactroban) [Topical Anti-infective] Uses lmpetigo CTadicate MRSA in nasal carriers Action -1- Bactmal protein synth Dose Topical Apply small amount to area 3 x /d x 5-14 d Nasal Apply bid in nostrils x 5d Caution [B, ] Contra Do not use w/ other nasal products Disp Oint, cream SE Local irritation, rash Interactions X Bacterial action W/ chloramphenicol EMS Monitor pt for super Infxn OD Unlikely, but not expected to produce life-threatening Sxs... 

Mechanism of Action An antibacterial agent that inhibits bacterial protein, RNA synthesis. Less effective on DNA synthesis. Nasal Eradicates nasal colonization of MRSA. Therapeutic Effect Prevents bacterial growth and replication. Bacteriostatic. Pharmacokinetics Metabolized in skin to inactive metabolite. Transported to skin surface removed by normal skin desquamation. 

Researchers from Takeda have isolated the antibiotics TAN-1057 A-D 29, 30 from Flexibacter sp. [67]. These (S)-/7-Lys-derived dipeptides have promising activity against clinically problematic methicillin-resistant strains of Staphylococcus aureus (MRSA). The /7-amino acid moiety is essential for the biological activity of TAN-1057 A 29. The bisguanidine 29 seems to have a dual mode of action, involving... 

While many natural products have been tested against hundreds of different strains of bacteria, the most common bacteria used in susceptibility tests include Bacillus cereus, Bacillus subtillis, Chlamydia pneumonia, Enterococcus faecalis, Escherichia coli, Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus pneumoniae, Klebsiella pneumoniae, vancomycin-resistant Enterococcus (VRE), Pseudomonas aeruginosa and Helicobacter pylori [18, 19], As the amount of published data describing the in vitro, in vivo and clinical antibacterial activities of natural products is so vast it could easily fill a book (or two), this review focuses only on natural products for which there is in vitro, in vivo and some clinical antibacterial data, as well as a plausible mechanism of action. 

The two unrelated streptogramins, quinupristin and dalfopristin, are used in combination (in a 30 70 ratio) to treat infections caused by staphylococci and enterococci (including MRSA and VRE). Their action is synergistic, and is generally bacteri-... 

Not a macrolide, but has the same mechanisms of action and resistance. Narrow spectrum gram-positive cocci (not MRSA) and anaerobes including B. fragilis (backup drug) has also been used in toxoplasmosis. Its concentration in bone has clinical value in osteomyelitis due to gram-positive cocci. First known drug to cause pseudomembranous colitis. 

Kubo, 1., Nihei, K.I., and Tsujimoto, K., Antibacterial action of anacardic acids against methicillin resistant Staphylococcus aureus (MRSA), J. Agric. Food Chem., 51, 7624—7628, 2003. 

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