Mouse oral toxicity

Barium peroxide is a strong oxidizer and can cause fire when in contact with combustible materials. It is a powerful irritant to skin, eyes, and mucous membranes (2). Consequendy, it is also toxic via the subcutaneous route protective clothing should be worn during handling. The LD q value (mouse, oral) is 50 mg/kg (2). 

The toxicity of sodium peroxoborate hexahydrate in solution is equivalent to those of sodium borate and hydrogen peroxide. The LD q (mouse, oral) is 1060 mg/kg (2). Local use of high concentrations in the mouth can cause chemical bums and other problems (25). No TLV has been estabhshed. 

Manufacture, Shipment, and Analysis. In the United States, sodium and potassium thiocyanates are made by adding caustic soda or potash to ammonium thiocyanate, followed by evaporation of the ammonia and water. The products are sold either as 50—55 wt % aqueous solutions, in the case of sodium thiocyanate, or as the crystalline soHds with one grade containing 5 wt % water and a higher assay grade containing a maximum of 2 wt % water. In Europe, the thiocyanates may be made by direct sulfurization of the corresponding cyanide. The acute LD q (rat, oral) of sodium thiocyanate is 764 mg/kg, accompanied by convulsions and respiratory failure LD q (mouse, oral) is 362 mg/kg. The lowest pubhshed toxic dose for potassium thiocyanate is 80—428 mg/kg, with hallucinations, convulsions, or muscular weakness. The acute LD q (rat, oral) for potassium thiocyanate is 854 mg/kg, with convulsions and respiratory failure. 

The only difficulty in this method (in addition to the calculations, which are easily carried out using computers) is the fact that it is impossible to analyse tables with values that are missing, so there is a need to choose substances for which there are a whole range of LC and LD values. Since this is impossible, three tables were used, which all have in common the L050 variables for rat and mouse, orally and by intraperitoneal means of penetration, so that the coherence of the three tables and a strong enough relationship between them could be ablished. The purpose was to determine, if, in the absence of one of the classification criteria set by regulation, it was possible to choose another available criterion to determine the risk level of toxicity. 

Repeat-dose toxicity such as 28-day dermal toxicity in rats and 90-day oral toxicity in at least two species (rat, dog,) 2-year toxicity and carcinogenicity (rat, mouse)... 

Acute Oral Toxicity TOPKAT Mouse Oral LD50... 

Although there can be no doubt that some PTXs are toxic to mice by i.p. administration, the question of whether these compotmds are orally toxic, or cause diarrhoea when administered orally, is more controversial. There have been relatively few oral dosing studies, due to the scarcity of high-pruity PTXs, and the results have not been consistent. However, recent evidence suggests that PTXs are weakly diarrhetic at most and are of relatively low oral toxicity. Based on their toxicity by the i.p. route in the mouse bioassay, PTX-1 and PTX-2 are currently regulated in shellfish together with okadaic acid... 

The LD50 in the rat after oral administration is 535mgkg. Oral toxicity to the mouse is less, with an LD50 of 1389 mg kg The rat LD50 after intra-peritoneal administration is 300 mg kg while that... 

Most of the toxicity data are for the 2,4- and 2,6-DNT isomers. Oral LD50 values for 2,4-DNT are extremely variable ranging from 177 to 609 mg kg day for rats and from 390 to 1647 mg kg for mice. Rat and mouse oral LD50 values of 216 and 607 mg kg respectively, have been reported for... 

Animals lethally intoxicated undergo CNS depression, narcosis, and respiratory arrest. Acute oral toxicity has been well characterized in the rat, mouse, rabbit, dog, and guinea pig with LD50 values, 8 6gkg, reported at very high oral doses. An average daily dose of 1.7g kg bw in male rats and 2.1 gkg bw in female rats has been shown to have no adverse... 

RTECS CLASS OF COMPOUND Primary Irritant. Acute Oral Toxicity (LD50) 6500 mg/kg [Mouse], Lowest Published Toxic Oral Dose (TDLo) 270 gm/kg/90D-C [Rat], Not listed as a carcinogen by IARC, NTP, ACGIH or OSHA. 

Vitamin E has not been associated with affecting genetic material or adverse reproductive effects in humans, however, when Vitamin E was given to mice in large doses, it was associated with growth retardation of the fetus and an increase in cleft palate. Furthermore, it did affect the genetic material of lab rats when doses of 2500 fig kg were administered intraperito-neally. Acute oral toxicity (LD50) >4000 mg/kg [Mouse],... 

Not considered a carcinogen by OSHA, IARC or NTR Acute inhalation toxicity (LD50) 110 mg/m3 [Rat]. Acute oral toxicity (LD50) 2.2 mg/kg [Mouse], 3.0 mg/kg [Rat],... 

Oral Toxicity (LD50) 9500 mg/kg [Mouse], Not listed as a carcinogen by IARC, NTP, ACGIH or OSHA. 

The uniqueness of bismuth is most characterized by its low toxic nature in spite of its heavy metal status in the nitrogen family, since it is a general trend of elements that the toxicity increases as you go down a group. Hence traditionally, it has been used widely in medicine and veterinary practice. Closely related arsenic and antimony compounds are generally highly toxic. LD50 (mg/ kg) values of bismuth oxychloride (BiOCl) and bismuth oxide are reported to be 22 000 (rat, oral) and 10 000 (mouse, oral), respectively. Accidental... 

M.S. Golub University of California Chronic oral toxicity of aluminum, manganese, and iron in mouse model US Department HHS/ Public Health Service... 

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