Intra-peritoneal administrations

Dosing techniques, such as intramuscular, intradermal, subcutaneous, and intra-peritoneal administration, can be used for the ferret. Care needs to be taken, however, when administering lipophilic compounds by the subcutaneous or intradermal routs, to avoid inadvertently injecting compounds into the ferret s thick layer of subcutaneous fat, which can result in poor absorption (Moody et al., 1985). 

Placental transfer of di(2-ethylhexyl) phthalate has been observed following intra-peritoneal administration of di(2-ethylhexyl) [car6o y/- C]phthalate on gestational day 5 or 10 in rats (Singh et al, 1975). The dams were killed at 24-h intervals starting on days 8 and 11 until day 20 of gestation. Radioactivity was detected in fetal tissues, amniotic fluid and placenta at all time points. The radioactivity peaked at 48 h and declined rapidly thereafter. The concentration was less than that in maternal blood and less than 1% of the administered dose. 

The LD50 in the rat after oral administration is 535mgkg. Oral toxicity to the mouse is less, with an LD50 of 1389 mg kg The rat LD50 after intra-peritoneal administration is 300 mg kg while that... 

Mercury has been shown to affect hepatic microsomal enzyme activity (Alexidis et al. 1994). Intra-peritoneal administration of mercuric acetate (6.2 mol/kg/day) once daily for 6 days or once as a single dose of 15. 68 mol/kg resulted in an increase in kidney weight and a significant decrease in total cytochrome P-450 content. The single 15.68 mol/kg injection resulted in the reduction of both microsomal protein level and P-450 content, possibly resulting from the generation of free radicals during the Hg intoxication process. 

After parenteral administration, ibogaine has been identified in various biological materials, including blood and urine (humans), and in the liver, kidney, and brain of laboratory animals 54,57-59). One hour after intra-peritoneal administration, high concentrations of ibogaine were present in rat liver and kidneys 60). After intravenous injection of 10 mg/kg to mice, maximal brain concentrations [48 ptg/g wet weight (—133 /iM)] were achieved in 105 (67). 

DMCM-Induced Seizures in Mice ED50 (mg/kg) After Intra-peritoneal Administration... 

The LD50 of epimedium extract in mice is 36 g/kg after intra-peritoneal administration and 56.8 g/kg after intravenous administration (Chen and Chen 2004). The LD51J of flavo-noids extracted from epimedium is 3 g/kg after intraperito-neal administration to mice (Leung and Foster 1996). 

The LD50 of melia fruit extract in rats is 1.03 g/kg after intra-peritoneal administration but could not be determined at doses up to 16 g/kg after oral administration (Carpinella... 

Maincent, P. Thouvenot, P. Amicabile, C. Hoffman, M. Kreuter, J. Couvreur, P. Devissaguet, J. P., Lymphatic targeting of polymeric nanoparticles after intra-peritoneal administration in rats. Pharmaceutical Research 1992, 9, (12), 1534-1539. 

Fukuda, S., Ikeda, M., Nakamura, M., et al., 2009b. Efficacy of oral and intra-peritoneal administration of CBMIDA for removing uranium in rats after parenteral injections of depleted uranium. Radiat. Prot. Dosim. 133, 12-19. 

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